4-Chlorophenylboronic acid Chemical Properties

Melting point:

284-289 °C(lit.)

Boiling point:

295.4±42.0 °C(Predicted)

Density 

1.32±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO

pka

8.39±0.10(Predicted)

form 

Crystalline Powder

color 

Off-white to beige

Water Solubility 

2.5 g/100 mL

BRN 

2936346

InChI

InChI=1S/C6H6BClO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,9-10H

InChIKey

CAYQIZIAYYNFCS-UHFFFAOYSA-N

SMILES

B(C1=CC=C(Cl)C=C1)(O)O

CAS DataBase Reference

1679-18-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

36-37/39-26

WGK Germany 

3

RTECS 

CY8950000

TSCA 

No

HazardClass 

IRRITANT

HS Code 

29319090

MSDS

• Language:English Provider:4-Chlorophenylboronic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Chlorophenylboronic acid Usage And Synthesis

Chemical Properties

off-white to beige crystalline powder

Chemical Properties

4-Chlorophenylboronic acid is white or off-white crystalline powder. It has certain solubility in water and is soluble in strong polar organic solvents such as dimethyl sulfoxide, but insoluble in ether solvents. It has similar chemical properties to phenylboronic acid.

Uses

4-Chlorobenzeneboronic Acid is used as a catalyst for the preparation of 4-hydroxycoumarin derivatives which display antitrypanosomal and antioxidant properties. It is also used as a catalyst for the asymmetric borane reduction of electron-deficient ketones.

Uses

4-Chlorophenylboronic acid can be used as a reactant in:

• Palladium-catalyzed direct arylation.
• Cyclopalladation.
• Tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation.
• Copper-mediated ligandless aerobic fluoroalkylation.
• Pd-catalyzed arylative cyclization.
• Ruthenium catalyzed direct arylation.
• Ligand-free copper-catalyzed coupling reactions.
• Regioselective arylation and alkynylation by Suzuki-Miyaura and Sonogashira cross-coupling reactions.

• Substituted diarylmethylidenefluorenes via Suzuki coupling reaction.
• Baclofen lactam by Suzuki coupling of a pyrrolinyl tosylate, followed by hydrogenation reaction.
• Palladium(II) thiocarboxamide complexes as Suzuki coupling catalysts.
• Biaryls by Suzuki reactions of aryl chlorides, bromides, and iodides with arylboronic acids.

4-Chlorophenylboronic acid(1679-18-1)Related Product Information

• 4-Chlorobenzoic acid
• ​4-Chlorophenoxyacetic acid sodium salt
• HexanitrodiphenylaMine
• Chlorphenamine maleate
• 1,2,4-Trichlorobenzene
• 4-Fluorobenzeneboronic acid
• Phenylboronic acid
• 4-Chlorobenzaldehyde
• Zinc borate
• 4-Chloronitrobenzene
• 4-Chloro-3-fluorobenzeneboronic acid
• (4-CHLORO-2-ETHOXYPHENYL)BORONIC ACID
• 2,4-Dichlorophenylboronic acid
• (3-AMINO-4-CHLOROPHENYL)BORONIC ACID HYDROCHLORIDE
• 4-Chloro-2-methoxyphenylboronic acid
• 4-CHLORO-2-METHYLPHENYLBORONIC ACID
• 4-Chloro-3-(trifluoromethyl)phenylboronic acid
• 2,4,6-Trichlorophenylboronic acid