URICASE
Description Source Background- Product Name
- URICASE
- CAS No.
- 9002-12-4
- Chemical Name
- URICASE
- Synonyms
- UAO;UA-R;UA-T;URICASE;C:C&B40;Uricozyme;EC 1.7.3.3;EC: 1.7.3.3;urikoxidase;Uratoxidase
- CBNumber
- CB3367414
- Molecular Formula
- C18H26N5O14P
- Formula Weight
- 567.397901
- MOL File
- 9002-12-4.mol
URICASE Property
- storage temp.
- -20°C
- form
- lyophilized powder
- color
- White to off-white
- biological source
- Bacillus sp. (B. fastidiosus)
- Water Solubility
- Hardly soluble in water, slightly soluble in buffer alkaline solution.
- Merck
- 13,9944
- Specific Activity
- 15-30units/mg protein (biuret)
- InChIKey
- VPXDHZMLJOJKOX-UHFFFAOYSA-N
- EPA Substance Registry System
- Oxidase, urate (9002-12-4)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- U0880
- Product name
- Uricase from Candida sp.
- Purity
- recombinant, expressed in E. coli, lyophilized powder, ≥2?units/mg solid
- Packaging
- 250units
- Price
- $172
- Updated
- 2025/07/31
- Product number
- U7128
- Product name
- Uricase from Arthrobacter globiformis
- Purity
- lyophilized powder, 15-30?units/mg protein (biuret)
- Packaging
- 100units
- Price
- $751
- Updated
- 2025/07/31
- Product number
- U0880
- Product name
- Uricase from Candida sp.
- Purity
- recombinant, expressed in E. coli, lyophilized powder, ≥2?units/mg solid
- Packaging
- 1000units
- Price
- $485.45
- Updated
- 2025/07/31
- Product number
- 94310
- Product name
- Uricase from Bacillus fastidiosus
- Purity
- lyophilized, ~9 U/mg
- Packaging
- 5mg
- Price
- $257
- Updated
- 2025/07/31
- Product number
- 94310
- Product name
- Uricase from Bacillus fastidiosus
- Purity
- lyophilized, ~9 U/mg
- Packaging
- 25mg
- Price
- $963
- Updated
- 2025/07/31
URICASE Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
Uricase is very important for the determination of uric acid in biological fluids. Uricase is an important medical enzyme which can be used to determine urate in clinical analysis. The enzyme Urate oxidase (UO) catalyzes the oxidation of uric acid to 5-hydroxyisourate.
Uses
Uricase from Arthrobacter globiformis has been used for coating the electrodes in - biosensor fabrication for the detection of uric acid in urine samples. It has also been used for analysing the effect of Zn, Cu, Mg, and Mn ions on uricase.
Uses
In the determination of serum and urine uric acid.
General Description
Mice deficient in uricase develop uric acid nephropathy and diabetes insipidus which can be mitigated with recombinant uricase treatment.
Biochem/physiol Actions
Uricase catalyzes the oxidation of uric acid to 5-hydroxyisourate, which subsequently forms (S)-allantoin. It is involved in purine metabolism, urate degradation and (S)-allantoin formation .
Description
Urate Oxidase Recombinant produced in E.Coli is a tetrameric, non-glycosylated polypeptide chain containing 302 amino acids, having a molecular formula of C1523H2383N417O462S7 and a molecular mass of 34,247 Dalton.
The cDNA coding for urate-oxidase was cloned from a strain of Aspergillus flavus . The monomer protein has no intra- or inter-disulfide bridges.
Source
Escherichia Coli
Background
Urate oxidase catalyzes the enzymatic oxidation (degrades) of uric acid into allantoin, an inactive and soluble metabolite, which is 5 to 10 fold more soluble than uric acid . Urate oxidase is an enzyme of the purine breakdown pathway that catalyses the oxidation of uric acid to allantoin. Uricase is present in numerous diverse organisms, but not in higher primates including human. Hyperuricaemia is most commonly associated with gout and also occurs in mammalians with malignancy, especially those with lymphoid malignancies due to rapid cell turnover and an increased rate of purine metabolism. Uricase is effective in the prevention and treatment of hyperuricaemia in mammalians with malignancy and in those who have undergone transplantation. It appears to act rapidly, safely and induces a more dramatic decrease in plasma levels of uric acid.
URICASE Preparation Products And Raw materials
Raw materials
Preparation Products
URICASE Suppliers
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View Lastest Price from URICASE manufacturers
- Product
- Uricase 9002-12-4
- Price
- US $0.00/KU
- Min. Order
- 1KU
- Purity
- ≥10unit/mg protein
- Supply Ability
- In stock
- Release date
- 2021-05-28
- Product
- URICASE 9002-12-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28
- Product
- Uricase 9002-12-4
- Price
- US $1.50/g
- Min. Order
- 1g
- Purity
- 99.0% Min
- Supply Ability
- 10kgs
- Release date
- 2025-03-31