ChemicalBook > CAS DataBase List > URICASE

URICASE

Description Source Background

Product Name: URICASE
CAS No.: 9002-12-4
Chemical Name: URICASE
Synonyms: UAO;UA-R;UA-T;URICASE;C:C&B40;Uricozyme;EC 1.7.3.3;EC: 1.7.3.3;urikoxidase;Uratoxidase
CBNumber: CB3367414
Molecular Formula: C18H26N5O14P
Formula Weight: 567.397901
MOL File: 9002-12-4.mol

Less

URICASE Property

storage temp.: -20°C
form: lyophilized powder
color: White to off-white
biological source: Bacillus sp. (B. fastidiosus)
Water Solubility: Hardly soluble in water, slightly soluble in buffer alkaline solution.
Merck: 13,9944
Specific Activity: 15-30units/mg protein (biuret)
InChIKey: VPXDHZMLJOJKOX-UHFFFAOYSA-N
EPA Substance Registry System: Oxidase, urate (9002-12-4)

Less

Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: YU7100000
F: 10-21
TSCA: Yes
HS Code: 35079090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: U0880
Product name: Uricase from Candida sp.
Purity: recombinant, expressed in E. coli, lyophilized powder, ≥2?units/mg solid
Packaging: 250units
Price: $172
Updated: 2025/07/31

Sigma-Aldrich

Product number: U7128
Product name: Uricase from Arthrobacter globiformis
Purity: lyophilized powder, 15-30?units/mg protein (biuret)
Packaging: 100units
Price: $751
Updated: 2025/07/31

Sigma-Aldrich

Product number: U0880
Product name: Uricase from Candida sp.
Purity: recombinant, expressed in E. coli, lyophilized powder, ≥2?units/mg solid
Packaging: 1000units
Price: $485.45
Updated: 2025/07/31

Sigma-Aldrich

Product number: 94310
Product name: Uricase from Bacillus fastidiosus
Purity: lyophilized, ~9 U/mg
Packaging: 5mg
Price: $257
Updated: 2025/07/31

Sigma-Aldrich

Product number: 94310
Product name: Uricase from Bacillus fastidiosus
Purity: lyophilized, ~9 U/mg
Packaging: 25mg
Price: $963
Updated: 2025/07/31

Less

URICASE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Uricase is very important for the determination of uric acid in biological fluids. Uricase is an important medical enzyme which can be used to determine urate in clinical analysis. The enzyme Urate oxidase (UO) catalyzes the oxidation of uric acid to 5-hydroxyisourate.

Uses

Uricase from Arthrobacter globiformis has been used for coating the electrodes in - biosensor fabrication for the detection of uric acid in urine samples. It has also been used for analysing the effect of Zn, Cu, Mg, and Mn ions on uricase.

Uses

In the determination of serum and urine uric acid.

General Description

Mice deficient in uricase develop uric acid nephropathy and diabetes insipidus which can be mitigated with recombinant uricase treatment.

Biochem/physiol Actions

Uricase catalyzes the oxidation of uric acid to 5-hydroxyisourate, which subsequently forms (S)-allantoin. It is involved in purine metabolism, urate degradation and (S)-allantoin formation .

Description

Urate Oxidase Recombinant produced in E.Coli is a tetrameric, non-glycosylated polypeptide chain containing 302 amino acids, having a molecular formula of C1523H2383N417O462S7 and a molecular mass of 34,247 Dalton.
The cDNA coding for urate-oxidase was cloned from a strain of Aspergillus flavus . The monomer protein has no intra- or inter-disulfide bridges.

Source

Escherichia Coli

Background

Urate oxidase catalyzes the enzymatic oxidation (degrades) of uric acid into allantoin, an inactive and soluble metabolite, which is 5 to 10 fold more soluble than uric acid . Urate oxidase is an enzyme of the purine breakdown pathway that catalyses the oxidation of uric acid to allantoin. Uricase is present in numerous diverse organisms, but not in higher primates including human. Hyperuricaemia is most commonly associated with gout and also occurs in mammalians with malignancy, especially those with lymphoid malignancies due to rapid cell turnover and an increased rate of purine metabolism. Uricase is effective in the prevention and treatment of hyperuricaemia in mammalians with malignancy and in those who have undergone transplantation. It appears to act rapidly, safely and induces a more dramatic decrease in plasma levels of uric acid.

URICASE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

URICASE Suppliers

China 238 Europe 2 Germany 5 India 5 Japan 3 Switzerland 1 United Kingdom 1 United States 14 Global 269

Shanghai Baoman Biotechnology Co., Ltd.

Tel: 021-62130998
Fax: 021-54438215
Email: baomanbio@163.com
Country: China
ProdList: 126
Advantage: 55

Shanghai Guchen Biotechnology Co., LTD

Tel: 021-34675735 19147740836
Email: 1986399151@qq.com
Country: China
ProdList: 9844
Advantage: 58

Amano Enzyme Manufacturing(China),Ltd. Shanghai Branch

Tel: 021-6249-0810 13611831109
Email: lihao_duan@amano-enzyme.com.cn
Country: China
ProdList: 44
Advantage: 58

Shanghai Titan Scientific Co.,Ltd

Tel: 16621234537
Email: chenyj@titansci.com
Country: China
ProdList: 10000
Advantage: 58

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3931
Advantage: 58

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-846993838003-8003 18013301590
Fax: 025-84699383-8003
Email: njduly@126.com
Country: China
ProdList: 3249
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7782
Advantage: 58

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3921
Advantage: 50

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Watson Biotechnology Co.,Ltd

Tel: 027-59207879 1972026995 18140587686
Fax: QQ：1972026995
Email: sales@3600chem.com
Country: China
ProdList: 4446
Advantage: 55

Hubei HongxinRuiYu Fine Chemical Co., Ltd.

Tel: 13477033894 13477038394
Fax: 027-65526669
Email: xuzixuan5200@foxmail.com
Country: China
ProdList: 137
Advantage: 58

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20794
Advantage: 60

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29759
Advantage: 68

Shanghai Yihe Biological Technology Co., Ltd.

Tel: 021-68882955 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 4991
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-59402396 13419635609
Fax: 027-83989310
Email: 13419635609@163.com
Country: China
ProdList: 1991
Advantage: 55

Wuhan Wsem Biological Co., Ltd.

Tel: 027-83778876 13667159345
Fax: 027-83778876
Email: 13667159345@163.com
Country: China
ProdList: 1997
Advantage: 55

Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.

Tel: 027-027-65526929 15102793023
Fax: 027-65526669
Email: hbhxry@foxmail.com
Country: China
ProdList: 1786
Advantage: 55

Hubei Yangxin Medical Technology Co., Ltd.

Tel: 15374522761
Fax: QQ:2853117752
Email: 3003392093@yongstandards.com
Country: China
ProdList: 10000
Advantage: 55

Guangzhou LES biological Technology Co.,Ltd.

Tel: 13672434928
Fax: -
Email: 3307355104@qq.com
Country: China
ProdList: 3650
Advantage: 58

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9750
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83778895 18602735115
Fax: 027-51119224
Email: 18602735115@163.com
Country: China
ProdList: 2005
Advantage: 64

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 14948
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 10063
Advantage: 58

Hefei Bomei Biotechnology Co., Ltd.

Tel: 13739298932
Email: 531626407@qq.com
Country: China
ProdList: 3010
Advantage: 58

Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.

Tel: 027-027-65385071 17771822910
Fax: 027-65526669
Email: shelleyl.meng@foxmail.com
Country: China
ProdList: 2354
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Hebei Yanxi Chemical Co., Ltd.

Tel: +8618531123677
Email: faithe@yan-xi.com
Country: China
ProdList: 5853
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23541
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Wuhan Fortuna Chemical Co., Ltd

Tel: +86-027-59207850 +86-13986145403;
Fax: 86-27-59524646
Email: info@fortunachem.com
Country: China
ProdList: 5990
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15109
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

HUNAN CHEMFISH SCIENTIFIC CO.,LTD

Tel: +86-0731-85567275 13298656710
Fax: QQ:3554193828
Email: sales05@chemfish.com
Country: China
ProdList: 7448
Advantage: 58

Xibao Biotechnology (Shanghai) Co., Ltd.

Tel: 13761246140
Email: 58642714@qq.com
Country: China
ProdList: 415
Advantage: 58

Wuhan Huibaixin Technology Co., Ltd.

Tel: 17364282875
Email: hbx66@qq.com
Country: CHINA
ProdList: 1550
Advantage: 58

Less

View Lastest Price from URICASE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Uricase 9002-12-4
Price: US $0.00/KU
Min. Order: 1KU
Purity: ≥10unit/mg protein
Supply Ability: In stock
Release date: 2021-05-28

Hebei Chuanghai Biotechnology Co., Ltd

Product: URICASE 9002-12-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Shaanxi Didu New Materials Co. Ltd

Product: Uricase 9002-12-4
Price: US $1.50/g
Min. Order: 1g
Purity: 99.0% Min
Supply Ability: 10kgs
Release date: 2025-03-31

9002-12-4, URICASERelated Search:

PHENYLSELENOL COBALT(II) ACETYLACETONATE Ethyl isocyanoacetate Cupric acetylacetonate Tosylmethyl isocyanide Aluminum acetylacetonate 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE METHYL ISOCYANOACETATE 2,4-PENTANEDIONE, SILVER DERIVATIVE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) N-BUTYLISOCYANIDE Benzyl isocyanide Tris(2,4-pentanedionato)chroMiuM(III) SALCOMINE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Ferric acetylacetonate Uric acid

EC 1.7.3.3

EC: 1.7.3.3

IUB: 1.7.3.3

URATE: O2 OXIDOREDUCTASE

URATE OXIDASE

URATE: OXIDOREDUCTASE

URATE: OXYGEN OXIDOREDUCTASE

URATE: OXYGEN OXOREDUCTASE

URICASE

URICASE, PIG LIVER

URICASE TYPE VIII-S

Uricase, Urate: oxygen oxidoreductase

UAO

Uricase recombinant, lyophil.

Uricase froM Candida utilis

Uricase from Bacillus fastidiosus

urico-oxidase

urikoxidase

Uricase from Candida sp.,Urate: oxygen oxoreductase

Uricase from Arthrobacter globiformis,Urate oxidase, Urate:O2 oxidoreductase

Uricase [>=10 units/mg]

Uratoxidase

Uric acid oxidase

Uricozyme

Urate oxidase (from Yeast)

uricase, bovine kidney

oxidase,urate

Uricase Bacillus fastidiosus

uricase from arthrobacter globiformis

uricase from bacillus fastidiosus lyoph. white powder

uricase from porcine liver

uricase microbial type vii from candida utilis

uricase type V

URICASE, RECOMBINANT

URICASE TYPE X FROM CORYNEBACTERIUM SPEC IES

URICASE TYPE II SOLUBLE POWDER FROM*BOVI NE KIDNEY

URICASE FROM PIG LIVER

URICASE FROM BACILLUS SP., ACTIVITY: 4.0 UNITS/MG

URICASE FROM CANDIDA UTILIS, ACTIVITY: LARGER THAN 3.0 UNITS/MG

UricaseExPigLiver(E.C.1.7.3.3)

Uricaseexpigliver

Uric oxidase

uricase from candida sp.

Urate oxidase, Urate:O2 oxidoreductase

Uricase, for bio, 10 units/mg

C:C&B40

URICASE USP/EP/BP

URICASE 9002-12-4

r-Uricase (Thermostable) ex. Yeast, 3U/mg

Uricase/UA-R

Uricase/UA-T

Uricase≥10u/mg

UA-R

Uric acid enzyme-imported

UA-T

UAO,URICASE

Uricase “Amano” 3

Uricase（UAO）