Tosylmethyl isocyanide Chemical Properties

Melting point:

109-113 °C(lit.)

Density 

1.2721 (rough estimate)

refractive index 

1.5270 (estimate)

storage temp. 

2-8°C

solubility 

water: slightly soluble

form 

Liquid

color 

Clear

Water Solubility 

insoluble

Sensitive 

Moisture Sensitive

Merck 

14,9556

BRN 

3592382

Exposure limits

NIOSH: IDLH 25 mg/m3

InChI

InChI=1S/C9H9NO2S/c1-8-3-5-9(6-4-8)13(11,12)7-10-2/h3-6H,7H2,1H3

InChIKey

BBNNLJMGPASZPD-UHFFFAOYSA-N

SMILES

S(C1C=CC(C)=CC=1)(=O)(=O)C[N+]#[C-]

CAS DataBase Reference

36635-61-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

23/24/25

Safety Statements 

36/37-45-38-36/37/39-28A

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

F 

21

Hazard Note 

Irritant

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29299000

MSDS

• Language:English Provider:(p-Tolylsulfonyl)methyl isocyanide
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Tosylmethyl isocyanide Usage And Synthesis

Description

Tosylmethyl isocyanide is a versatile synthon in organic chemistry, widely used as a reagent for the preparation of biologically active pyrroles and imidazoles. Tosylmethyl isocyanide undergoes a base-promoted 1,3-dipolar cycloaddition reaction with immobilised imines under microwave irradiation to give 1,5-disubstituted imidazoles.

Chemical Properties

Pale yellow to light brown crystalline powder

Uses

Tosylmethyl Isocyanide is used as a synthetic reagent in the preparation of variety or biologically active heterocycles such as pyrroles and imidazoles. Tosylmethyl Isocyanide is reported to inhibit [ Fe]-hydrogenase with very high affinity.

Definition

Tosylmethyl isocyanide is a chemical compound of cyanide that Versatile synthon in organic chemistry, especially in the synthesis of heterocyclic Compounds.

Preparation

N-(p-Tolylsulfonylmethyl)formamide 1609:

A 3-L, three-necked, round-bottomed flask, equipped with a mechanical stirrer, a condenser, and a thermometer, was charged with sodium p-toluenesulfinate 1606 (267 g, 1.5 mol). After the addition of water (750 mL), a 34–37% solution of formaldehyde 1607 (350 mL, 378 g, ca. 4.4 mol), formamide 1608 (600 mL, 680 g, 15 mol), and formic acid (200 mL, 244 g, 5.3 mol), the stirred reaction mixture was heated at 90 C°. The sodium p-toluenesulfinate dissolved during the heating, and the clear solution was kept at 90–95 C° for 2 h. It was then cooled in an ice/salt bath with continued stirring and further cooled overnight in a freezer at 20 C°. The white solid produced was collected by suction filtration. It was washed thoroughly in a beaker by stirring with three 250 mL portions of iced water. The product was dried under reduced pressure over phosphorus pentoxide at 70 C° to provide 134–150 g (42–47%) of crude N-(p-tolylsulfonylmethyl)formamide 1609; mp 106–110 C°. This product was sufficiently pure to be used directly in the following reaction.

Application

Tosylmethyl isocyanide was used:
(1) in the synthesis of triplet drugs with the 1,3,5-trioxazatriquinane skeleton;
(2) as reagent in the preparation of biologically active pyrroles and imidazoles;
(3) as the isonitrile component in a diastereoselective Passerini reaction employing sugar-derived aldehydes.

Purification Methods

Use an efficient fume cupboard. Purify TOSMIC by dissolving (50g) in CH2Cl2 (150mL) and passing it through a column (40x3cm) containing neutral alumina (100g) in CH2Cl2 and eluting with CH2Cl2. A nearly colourless solution (700mL) is collected, evaporated in vacuo and the residue (42-47g) of TOSMIC (m 113-114o dec) is recrystallised once from MeOH (m 116-117o dec). [Hoogenboom et al. Org Synth 57 102 1977, Lensen Tetrahedron Lett 2367 1972.] It also crystallises from EtOH (charcoal) [Saito & Itano, J Chem Soc, Perkin Trans 1 1 1986].

Tosylmethyl isocyanide(36635-61-7)Related Product Information

• Methylparaben
• Methyl acrylate
• Molybdic acid
• Sulfosulfuron
• Kresoxim-methyl
• Basic Violet 1
• Ammonium acetate
• Ammonium carbonate
• Ammonium sulfate
• Paraquat dichloride
• Ammonium dihydrogen phosphate
• Tosyl cyanide
• Acetonitrile
• Methanol
• p-Tolunitrile
• Methyl acetate
• Ammonium hydroxide
• Ammonium chloride