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D-Glucosamine hydrochloride

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D-Glucosamine hydrochloride Basic information

Product Name:
D-Glucosamine hydrochloride
Synonyms:
  • 2-DESOXY-2-AMINO-D-GLUCOSE HYDROCHLORIDE
  • 2-AMINO-D-GLUCOSE HYDROCHLORIDE
  • 2-AMINO-2-DEOXY-D-GLUCOPYRANOSE HYDROCHLORIDE
  • 2-AMINO-2-DEOXY-D-GLUCOSE HCL
  • 2-AMINO-2-DEOXY-D-GLUCOSE HYDROCHLORIDE
  • D-(+)-GLUCOSAMINE HCL
  • D-GLUCOSAMINE HCL
  • D(+)-GLUCOSAMINE HYDROCHLORIDE
CAS:
66-84-2
MF:
C6H14ClNO5
MW:
215.63
EINECS:
200-638-1
Product Categories:
  • Anilines, Aromatic Amines and Nitro Compounds
  • Inhibitors
  • Aminosugars
  • Biochemistry
  • Other APIs
  • Food additives
  • Glucose
  • Sugars
  • Nutritional Supplements
  • Dextrins、Sugar & Carbohydrates
  • Biological and chemical
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • Food & Flavor Additives
  • Amines
  • Carbohydrates & Derivatives
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
66-84-2.mol
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D-Glucosamine hydrochloride Chemical Properties

Melting point:
190-194 °C (dec.)(lit.)
alpha 
72.5 º (c=2, H2O, 5hrs.)
refractive index 
72 ° (C=1, H2O)
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, colorless
form 
crystalline
Water Solubility 
soluble
Merck 
14,4458
BRN 
4157370
Stability:
Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKey
QKPLRMLTKYXDST-LPRXMDNASA-N
CAS DataBase Reference
66-84-2(CAS DataBase Reference)
EPA Substance Registry System
D-Glucose, 2-amino-2-deoxy-, hydrochloride (66-84-2)
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Safety Information

Hazard Codes 
F,Xi,Xn
Risk Statements 
21-36/38-46-62-63
Safety Statements 
24/25-53-36/37-26-25
WGK Germany 
2
RTECS 
LZ6665000
3-10
Hazard Note 
Highly Flammable
TSCA 
Yes
HS Code 
29329985

MSDS

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D-Glucosamine hydrochloride Usage And Synthesis

Chemical Properties

white powder

Uses

Novel application of D-Glucosamine hydrochloride to prepare medical agent for treating vertigo. Found in chitin, in mucoproteins, and in mucopolysaccharides. Antiarthritic. Recent studies show that its chondroprotective activity is related to its antiapoptic properties.

Uses

glucosamine hydrochloride (glucosamine HCl) is used to adjust the pH of a formulation. It also has anti-static and hair-conditioning properties.

Purification Methods

Crystallise the hydrochloride from 3M HCl, water, and finally water/EtOH/acetone as for galactosamine hydrochloride. [Purchase & Braun Org Synth 26 36 1946, Stacey & Webber Methods in Carbohydrate Chemistry I 228 1962, Academic Press.] The salt has also been purified by dissolving in the minimum volume of boiling H2O (charcoal), filtering and adding a large excess of 95% EtOH (~4 volumes) and stirring vigorously for several hours. Collect the crystals after 4-6hours to give  anomer which mutarotates ] D +100o to +72o (equilibrium, c 1, H2O). A large amount of the -anomer stays in solution. This can be precipitated from the filtrate by adding excess Et2O. The mixture of -plus -anomers has [] D +68.8o (c 4.75, H2O, mutarotating to +70.1o)[Leaback Biochemical Preparations 10 118 1963]. Note that if Et2NH is used instead of Et3N, conversion to the -anomer can be complete (see above). [Stacey et al. Methods in Carbohydrate Chemistry I 3061962, Academic Press; Beilstein 4 IV 2018.]

D-Glucosamine hydrochloride Preparation Products And Raw materials

Raw materials

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