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Aminoacetonitrile hydrochloride

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Aminoacetonitrile hydrochloride Basic information

Product Name:
Aminoacetonitrile hydrochloride
Synonyms:
  • aminoacetonitrilemonohydrochloride
  • amino-acetonitrilmonohydrochloride
  • glycinonitrile,monohydrochloride
  • 2-AminoacetonitrileHydrochloride
  • GlycinonitrileHCl
  • Aminoacetonitrilehydrochloride,97%
  • Acetonitrile, amino-, monohydrochloride
  • AMINOACETONITRILE A.K.A. GLYCINONITRILE HYDROCHLOR
CAS:
6011-14-9
MF:
C2H5ClN2
MW:
92.53
EINECS:
227-865-9
Product Categories:
  • Pharmaceutical Intermediates
  • straight chain compounds
Mol File:
6011-14-9.mol
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Aminoacetonitrile hydrochloride Chemical Properties

Melting point:
172-174°C
RTECS 
MC1950000
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Methanol (Slightly, Heated), Water
form 
Powder
color 
White to Off-White
Water Solubility 
Soluble in water 20°C, 1000g/L.
Sensitive 
Hygroscopic
Merck 
14,412
CAS DataBase Reference
6011-14-9(CAS DataBase Reference)
EPA Substance Registry System
Aminoacetonitrile hydrochloride (6011-14-9)
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Safety Information

Risk Statements 
20/21/22-36/37/38-25
Safety Statements 
22-36/37-45-26
RIDADR 
3439
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29269090

MSDS

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Aminoacetonitrile hydrochloride Usage And Synthesis

Chemical Properties

White to light brown solid

Uses

Used as pharmaceutical intermediates, organic synthetic raw material transportation.

Application

Aminoacetonitrile is a useful synthetic intermediate. It is a reagent used to synthesize dipeptide nitriles as reversible and potent cathepsin S inhibitors. It can also used to prepare substituted cyclic ureas as possible HIV protease inhibitors.

Preparation

Synthesis of Aminoacetonitrile Hydrochloride by Reaction of Aminoacetonitrile with Hydrogen Chloride in Methanol: mixing the aminoacetonitrile with hydrogen chloride methanol solution, reacting at 45-50°C for 1-2 hours, cooling to below 5°C, filtering, and centrifugalizing to obtain the aminoacetonitrile hydrochloride, wherein in the hydrogen chloride methanol solution, the content of hydrogen chloride is 30-50 wt%, and the water content is less than or equal to 1%.
Preparation method of aminoacetonitrile hydrochloride

Safety Profile

An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl.

Purification Methods

The salt recrystallises from dilute EtOH as hygroscopic leaflets. It is best to crystallise it from absolute EtOH/Et2O (1:1) and then recrystallise it from absolute EtOH. The melting point recorded ranges from 144o to 174o. The free base has b 58o/15mm with partial decomposition. [Klages J Prakt Chem [2] 65 189 1902, Mange J Am Chem Soc 56 2197 1934, Goldberg & Kelly J Chem Soc 1371 1947, Beilstein 4 H 344, 4 I 468, 4 II 783, 4 III 1120, 4 IV 2363.]

Aminoacetonitrile hydrochloride Preparation Products And Raw materials

Preparation Products

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