Aminoacetonitrile hydrochloride Chemical Properties

Melting point:

172-174°C

RTECS 

MC1950000

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Methanol (Slightly, Heated), Water

form 

Powder

color 

White to Off-White

Water Solubility 

Soluble in water 20°C, 1000g/L.

Sensitive 

Hygroscopic

Merck 

14,412

CAS DataBase Reference

6011-14-9(CAS DataBase Reference)

EPA Substance Registry System

Aminoacetonitrile hydrochloride (6011-14-9)

Safety Information

Risk Statements 

20/21/22-36/37/38-25

Safety Statements 

22-36/37-45-26

RIDADR 

3439

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29269090

MSDS

• Language:English Provider:Aminoacetonitrile hydrochloride
• Language:English Provider:ALFA

Aminoacetonitrile hydrochloride Usage And Synthesis

Chemical Properties

White to light brown solid

Uses

Used as pharmaceutical intermediates, organic synthetic raw material transportation.

Application

Aminoacetonitrile is a useful synthetic intermediate. It is a reagent used to synthesize dipeptide nitriles as reversible and potent cathepsin S inhibitors. It can also used to prepare substituted cyclic ureas as possible HIV protease inhibitors.

Preparation

Synthesis of Aminoacetonitrile Hydrochloride by Reaction of Aminoacetonitrile with Hydrogen Chloride in Methanol: mixing the aminoacetonitrile with hydrogen chloride methanol solution, reacting at 45-50°C for 1-2 hours, cooling to below 5°C, filtering, and centrifugalizing to obtain the aminoacetonitrile hydrochloride, wherein in the hydrogen chloride methanol solution, the content of hydrogen chloride is 30-50 wt%, and the water content is less than or equal to 1%.
Preparation method of aminoacetonitrile hydrochloride

Safety Profile

An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl.

Purification Methods

The salt recrystallises from dilute EtOH as hygroscopic leaflets. It is best to crystallise it from absolute EtOH/Et2O (1:1) and then recrystallise it from absolute EtOH. The melting point recorded ranges from 144o to 174o. The free base has b 58o/15mm with partial decomposition. [Klages J Prakt Chem [2] 65 189 1902, Mange J Am Chem Soc 56 2197 1934, Goldberg & Kelly J Chem Soc 1371 1947, Beilstein 4 H 344, 4 I 468, 4 II 783, 4 III 1120, 4 IV 2363.]

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