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AMINOGUANIDINE HYDROCHLORIDE

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AMINOGUANIDINE HYDROCHLORIDE Basic information

Product Name:
AMINOGUANIDINE HYDROCHLORIDE
Synonyms:
  • 2-aminoguanidine hydrochloride
  • Aminoguanadine hydrochloride 98%
  • Metformin Impurity 15(Aminoguanidine hydrochloride)
  • Aminoguanadine hydrochloride
  • amino-guanidinhydrochloride
  • hydrazinecarboximidamidehydrochloride
  • carbazamidine monohydrochloride
  • AMINOGUANIDINE HYDROCHLORIDE, 98+%
CAS:
1937-19-5
MF:
CH7ClN4
MW:
110.54608
EINECS:
217-707-7
Product Categories:
  • Signalling
  • TUSACAPINE
  • Pharmaceutical Intermediates
  • Nitric Oxide
Mol File:
1937-19-5.mol
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AMINOGUANIDINE HYDROCHLORIDE Chemical Properties

Melting point:
162-166 °C(lit.)
vapor pressure 
0Pa at 25℃
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Completely soluble in water
form 
Crystals
color 
White to off-white
Water Solubility 
506.7g/L at 20℃
Merck 
13,440
BRN 
3909606
LogP
-3.55 at 20℃
CAS DataBase Reference
1937-19-5(CAS DataBase Reference)
EPA Substance Registry System
Hydrazinecarboximidamide, monohydrochloride (1937-19-5)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
ME8430000
10-21
HS Code 
29280000
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AMINOGUANIDINE HYDROCHLORIDE Usage And Synthesis

Uses

Aminoguanidine Hydrochloride is used in the synthetic preparation of highly selective and potent G-protein-coupled receptor kinase 2 (GRK2) inhibitor for potential treatment of heart failure.

Description

Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS. The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 μM, respectively. Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.

Chemical Properties

white to off-white crystals

Uses

antitussive

Uses

Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both Escherichia coli and Staphylococcus aureus.

Uses

a-Glucosidase inhibitor; hydroxyethyl derivative of 1-deoxynojirimycin

General Description

Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Inhibits both constitutive and inducible nitric oxide synthetase.

AMINOGUANIDINE HYDROCHLORIDESupplier

Jiaxing Dongliang Pharmaceutical Technology Co.,Ltd. Gold
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