D-Glucosamine sulfate Chemical Properties

Melting point:

116 °C

Boiling point:

617.6±55.0 °C

storage temp. 

Inert atmosphere,2-8°C

solubility 

Soluble at 1mg/ml in 1M HCl

form 

Powder

color 

White to Off-white

LogP

-2.375 (est)

CAS DataBase Reference

29031-19-4(CAS DataBase Reference)

D-Glucosamine sulfate Usage And Synthesis

Chemical Properties

White Powder

Uses

Novel application of glucosamine to prepare medical agent for treating vertigo. Found in chitin, in mucoproteins, and in mucopolysaccharides. Antiarthritic.

Uses

Pharmaceutic aid.

Uses

D-Glucosamine Sulfate is used on the syntheis of aryl β-N-acetylglucosaminides modified at C-6 as potential antimicrobial agents.

Synthesis

1. 17.9 g (0.1 mol) of halide-free glucosamine base and 125 mL of pure water were added to the reaction vessel and the mixture was stirred until the base was completely dissolved. 2. 11.5 g of polyethylene glycol homopolymer with a molecular weight of 4,000 was added and stirring was continued until a clarified solution was formed. 3. the solution was cooled to 5-10°C, and 4.9 g of concentrated sulfuric acid was slowly added while maintaining stirring and controlling the temperature in the range of 5-10°C. 4. after the sulfuric acid was added, the temperature was confirmed to be within the range of 5-10°C. 4. After the addition of sulfuric acid, the pH of the reaction mixture was confirmed to be 3.5 and stirring was continued for 30 minutes. 5. The product was isolated by freeze-drying at a pressure of about 200 mTorr and a temperature of -45 °C to give stable glucosamine sulfate. 6. The product was snow-white in color, and the temperature was controlled in the range of 5-10 °C. 6. The product was snow white in color with a yield of 33 g (96% yield). The specific optical rotation of glucosamine sulfate was measured to be +62.99°. 7. 7. The product was stored in a capped vial at room temperature. The product remained snow white when observed after one year.

IC 50

Human Endogenous Metabolite

References

[1] Patent: US7388001, 2008, B1. Location in patent: Page/Page column 6
[2] Patent: US7388001, 2008, B1. Location in patent: Page/Page column 6

D-Glucosamine sulfate (29031-19-4)Related Product Information

• D-Glucose monohydrate
• Ammonium sulfate
• D-Glucosamine hydrochloride
• Ferrous sulfate monohydrate
• calcium sulfate
• Sodium sulfate
• Potassium sulfate
• Glucosamine
• Heparitin, sulfate
• sulfate
• D-GLUCOSAMINE SULFATE 2KCL,Glucosamine sulfate
• GLUCOSAMINE SULFATE POTASSIUM CHLORIDE
• D-GLUCOSAMINE SULFATE 2NACL
• N-Sulfo-glucosamine sodium salt
• Glucosamine Sulfate 2KCL
• GLUCOSAMINE SULFATE SODIUM CHLORIDE
• P-NITROPHENYL 6-SULFO-2-ACETAMIDO-2-DEOXY-B-D-GLUCOPYRANOSIDE, POTASSIUM SALT
• 4-Methylumbelliferyl2-acetamido-2-deoxy-a-D-glucopyranoside-6-O-sulfatepotassiumsalt