(R)-2-Flurbiprofen Chemical Properties

Melting point:

110-113 °C(lit.)

Boiling point:

376.2±30.0 °C(Predicted)

Density 

1.199±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

DMF: 25 mg/ml; DMSO: 10 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): .9 mg/ml

form 

Crystalline Powder

pka

4.14±0.10(Predicted)

color 

White to off-white

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

HS Code 

29163900

MSDS

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(R)-2-Flurbiprofen Usage And Synthesis

Description

(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen that has diverse biological activities. It inhibits γ-secretase activity in vitro and, in vivo, it reduces formation of amyloid-β peptide 1-42 (Aβ42) and improves axonal transport in young Aβ-plaque free mice but not old mice with existing Aβ plaques in the Tg2576 transgenic model of Alzheimer''s disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-κB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75^NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.

Uses

(R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.

Definition

ChEBI: (R)-flurbiprofen is a flurbiprofen. It is an enantiomer of a (S)-flurbiprofen.

Biochem/physiol Actions

gamma secretase inhibitor; amyloid Abeta 42 lowering agent

(R)-2-Flurbiprofen(51543-40-9)Related Product Information

• Kresoxim-methyl
• Methylparaben
• Ethyl 2-(Chlorosulfonyl)acetate
• Biphenyl
• (Trifluoromethyl)trimethylsilane
• 2-Fluorophenylacetic acid
• 2-Phenylisobutyric acid
• Phenylmethylsulfonyl fluoride
• α-Lipoic Acid
• 4-Biphenylacetic acid
• Flurbiprofen
• 2-Methylbenzotrifluoride
• Bensulfuron methyl
• Methyl acrylate
• Trifluoromethanesulfonic anhydride
• 3-(Trifluoromethyl)benzaldehyde
• 3-（trifluoromethyl) Cinnamaldehyde
• Methyl