(R)-2-Flurbiprofen
- Product Name
- (R)-2-Flurbiprofen
- CAS No.
- 51543-40-9
- Chemical Name
- (R)-2-Flurbiprofen
- Synonyms
- Tarenflurbil;(R)-FLURBIPROFEN;Flurizan;Furbiprofen;2-Flurbiprofen;E-7869;(R)-FL;MPC 7869;Flurbiprofene;l-Flurbiprofen
- CBNumber
- CB8302496
- Molecular Formula
- C15H13FO2
- Formula Weight
- 244.26
- MOL File
- 51543-40-9.mol
(R)-2-Flurbiprofen Property
- Melting point:
- 110-113 °C(lit.)
- Boiling point:
- 376.2±30.0 °C(Predicted)
- Density
- 1.199±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMF: 25 mg/ml; DMSO: 10 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): .9 mg/ml
- form
- Crystalline Powder
- pka
- 4.14±0.10(Predicted)
- color
- White to off-white
Safety
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- HS Code
- 29163900
N-Bromosuccinimide Price
- Product number
- 70255
- Product name
- (R)-Flurbiprofen
- Purity
- ≥99%
- Packaging
- 100mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 70255
- Product name
- (R)-Flurbiprofen
- Purity
- ≥99%
- Packaging
- 1g
- Price
- $133
- Updated
- 2024/03/01
- Product number
- 70255
- Product name
- (R)-Flurbiprofen
- Purity
- ≥99%
- Packaging
- 250mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 70255
- Product name
- (R)-Flurbiprofen
- Purity
- ≥99%
- Packaging
- 500mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- F598730
- Product name
- (R)-Flurbiprofen
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
(R)-2-Flurbiprofen Chemical Properties,Usage,Production
Description
(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen that has diverse biological activities. It inhibits γ-secretase activity in vitro and, in vivo, it reduces formation of amyloid-β peptide 1-42 (Aβ42) and improves axonal transport in young Aβ-plaque free mice but not old mice with existing Aβ plaques in the Tg2576 transgenic model of Alzheimer''s disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-κB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.
Uses
(R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.
Definition
ChEBI: (R)-flurbiprofen is a flurbiprofen. It is an enantiomer of a (S)-flurbiprofen.
Biochem/physiol Actions
gamma secretase inhibitor; amyloid Abeta 42 lowering agent
(R)-2-Flurbiprofen Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-2-Flurbiprofen Suppliers
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View Lastest Price from (R)-2-Flurbiprofen manufacturers
- Product
- (R)-2-Flurbiprofen 51543-40-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-18
- Product
- (R)-2-Flurbiprofen 51543-40-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-11
- Product
- (R)-2-Flurbiprofen 51543-40-9
- Price
- US $90.00/KG
- Min. Order
- 10KG
- Purity
- 99.9%
- Supply Ability
- 100tons
- Release date
- 2021-10-29