4-Biphenylacetic acid
- Product Name
- 4-Biphenylacetic acid
- CAS No.
- 5728-52-9
- Chemical Name
- 4-Biphenylacetic acid
- Synonyms
- FELBINAC;Napageln;BIPHENYL-4-ACETIC ACID;[1,1'-BIPHENYL]-4-ACETIC ACID;2-([1,1'-biphenyl]-4-yl)acetic acid;L-141;TraxaM;LY-61017;Seltouch;CI 83544
- CBNumber
- CB0186272
- Molecular Formula
- C14H12O2
- Formula Weight
- 212.24
- MOL File
- 5728-52-9.mol
4-Biphenylacetic acid Property
- Melting point:
- 159-160 °C (lit.)
- Boiling point:
- 312.08°C (rough estimate)
- Density
- 1.1035 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble50mg/mL, clear, colorless to yellow
- form
- Powder
- pka
- 4.29±0.10(Predicted)
- color
- Beige
- Water Solubility
- 39.27mg/L(25 ºC)
- Merck
- 14,3316
- BRN
- 1211592
- InChI
- InChI=1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16)
- InChIKey
- QRZAKQDHEVVFRX-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=CC=C2)=CC=C(CC(O)=O)C=C1
- CAS DataBase Reference
- 5728-52-9(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xn
- Risk Statements
- 23/25-36/37/38-25-36/37/38/63-20/21/22
- Safety Statements
- 26-36/37/39-45-37/39-28A-26/36/3745/60-20-36
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- DU8229050
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29163900
- Toxicity
- LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y0000731
- Product name
- Felbinac
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 10 mg
- Price
- $159
- Updated
- 2025/07/31
- Product number
- 196487
- Product name
- 4-Biphenylacetic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $43.47
- Updated
- 2025/07/31
- Product number
- 196487
- Product name
- 4-Biphenylacetic acid
- Purity
- 98%
- Packaging
- 25g
- Price
- $120
- Updated
- 2023/01/07
- Product number
- B1278
- Product name
- 4-Biphenylacetic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $41
- Updated
- 2025/07/31
- Product number
- B1278
- Product name
- 4-Biphenylacetic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 250g
- Price
- $232
- Updated
- 2025/07/31
4-Biphenylacetic acid Chemical Properties,Usage,Production
Description
Felbinac Is the active metabolite of the non-steroidal antiinflammatory agent, fenbufen. Applied topically as a gel to joints, it is useful in the symptomatic relief of articular inflammation and pain.
Chemical Properties
Off-white powder
Originator
Lederle (USA)
Uses
Anti-inflammatory, analgesic drug.
Uses
4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug.
Definition
ChEBI: Biphenyl-4-ylacetic acid is a monocarboxylic acid in which one of the alpha-hydrogens is substituted by a biphenyl-4-yl group. An active metabolite of fenbufen, it is used as a topical medicine to treat muscle inflammation and arthritis. It has a role as a non-steroidal anti-inflammatory drug. It is a member of biphenyls and a monocarboxylic acid. It contains a biphenyl-4-yl group. It is functionally related to an acetic acid.
brand name
Dolinac (Wyeth-Ayerst); Flexfree(Wyeth-Ayerst); Napageln (Wyeth-Ayerst); Target (Wyeth-Ayerst); Traxam (Wyeth-Ayerst).
General Description
4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors.
Safety Profile
Poison by subcutaneous route.Moderately toxic by ingestion and intraperitoneal routes.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits acrid smoke and fumes.
Synthesis
First 4-aminophenylacetic acid is prepared by reducing 4-nitrophenylacetic acid in the presence of a palladium-carbon catalyst; 4-Biphenylacetic acid is finally prepared by reacting 4-aminophenylacetic acid with benzene in the presence of sodium nitrite and an acid.
4-Biphenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Biphenylacetic acid manufacturers
- Product
- 4-Biphenylacetic acid 5728-52-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20tongs
- Release date
- 2025-08-21
- Product
- 4-Biphenylacetic acid 5728-52-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2025-08-14
- Product
- 4-Biphenylacetic acid 5728-52-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-12