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Antipyrine

Basic information Safety Supplier Related

Antipyrine Basic information

Product Name:
Antipyrine
Synonyms:
  • 1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on
  • 1,5-Dimethyl1-2-phenyl-3-pyrazolone
  • phenazone(pharmaceutical)
  • Phenozone
  • Phenyldimethyl isopropyl pyrazolone
  • Phenylon
  • Phenylone
  • Pyrazophyl
CAS:
60-80-0
MF:
C11H12N2O
MW:
188.23
EINECS:
200-486-6
Product Categories:
  • Building Blocks
  • C11
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Lipid signaling
  • Chemical Synthesis
  • Aromatics
  • Heterocycles
  • Heterocyclic Building Blocks
  • Pyrazoles
  • PARODYNE
Mol File:
60-80-0.mol
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Antipyrine Chemical Properties

Melting point:
109-111 °C(lit.)
Boiling point:
319 °C
Density 
1,19 g/cm3
refractive index 
1.5850 (estimate)
storage temp. 
2-8°C
solubility 
H2O: soluble1 gm in less than 1ml
pka
pKa 1.4 (Uncertain)
form 
Crystalline Powder
color 
White
Water Solubility 
1000 g/L (20 ºC)
Merck 
14,716
BRN 
157775
Stability:
Stable. Incompatible with ammonia, strong acids, alkalies, strong oxidizing agents, metallic salts, phenol.
CAS DataBase Reference
60-80-0(CAS DataBase Reference)
NIST Chemistry Reference
Antipyrine(60-80-0)
EPA Substance Registry System
Antipyrine (60-80-0)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36-37/39
RIDADR 
3249
WGK Germany 
1
RTECS 
CD2450000
10
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29331190
Toxicity
LD50 orally in rats: 1.8 g/kg (Hart)

MSDS

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Antipyrine Usage And Synthesis

Chemical Properties

White Powder

Uses

Analgesic; used to test hepatic drug-metabolizing activity.

Definition

ChEBI: A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at C-1 and C-5 and with a phenyl group at N-2.

brand name

Aerol;Antigestin;Asthma dellipsoids;Aurafair;Auralgicin;Auraltone;Bajumol;Breezeazy;Calmasmin;Cetussan;Codalgin;Crema antisolar evanescente;Doleron novum;Dolo-med-much;Dol-stop;Kalopsis;Lanceotic;Lavylgan;Mig-antos;Migranin;Natt-lunedon;Neo-felsol;Orecil;Otipyrin;Otosan-sulfan;Otothricinol;Palacaine;Pasta antisola;Pomada heridas;Prednefrin;Prefrin liquifilm;Prefrin z;Priatan;Prophyllen;Remolmed;Salicopil;Sedaural;Sedonan;Shhe 21;Spalt n;Tympagesic;Visublefarite.

World Health Organization (WHO)

Phenazone is a pyrazolone derivative chemically related to aminophenazone. Some regulatory authorities have imposed restrictions on its use on these grounds. However, a recent international study showed no statisticallybased evidence of an association with agranulocytosis or aplastic anaemia. Nor does it share with aminophenazone the propensity to produce potentially carcinogenic nitrosamines.

Safety Profile

A human Doison bv 1 i an unspecified route. Moderately toxic via ingestion, subcutaneous, and intravenous routes. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Antipyrine crystallises from EtOH/water mixture, *benzene, *benzene/pet ether or hot water (charcoal), and the crystals are dried under a vacuum. [Beilstein 24 H 27, 24 III/IV 75.]

Antipyrine Preparation Products And Raw materials

Raw materials

Preparation Products

AntipyrineSupplier

Shanghai Longsheng chemical Co.,Ltd. Gold
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021-58099652-8005;021-58099637-8009
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bin.wu@shlschem.com;sales@shlschem.com
J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
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21-61259100-
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sh@meryer.com
Alfa Aesar
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400-610-6006; 021-67582000
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saleschina@alfa-asia.com
TCI (Shanghai) Development Co., Ltd.
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021-67121386 / 800-988-0390
Email
Sales-CN@TCIchemicals.com