4-Aminoantipyrine Chemical Properties

Melting point:

105-110 °C(lit.)

Boiling point:

340 C

Density 

0.8

refractive index 

1.4930 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

H₂O: 0.1 g/mL, clear

pka

pK1: 4.94(+1) (25°C)

form 

Powder or Crystals

color 

Yellow to yellow-brown

Odor

Odorless

PH

7.1 (100g/l, H2O, 20℃)(slurry)

Water Solubility 

ca. 500 g/L (20 ºC)

Merck 

14,591

BRN 

181635

Stability:

Stable. May be light sensitive.

CAS DataBase Reference

83-07-8(CAS DataBase Reference)

NIST Chemistry Reference

Aminoantipyrene(83-07-8)

EPA Substance Registry System

4-Aminoantipyrene (83-07-8)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38-20/21/22

Safety Statements 

26-36-36/37/39

WGK Germany 

3

RTECS 

CD2480000

F 

8-9-23

Hazard Note 

Harmful

TSCA 

Yes

HS Code 

29331190

Toxicity

LD50 orally in Rabbit: 1700 mg/kg

MSDS

• Language:English Provider:Ampyrone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Aminoantipyrine Usage And Synthesis

Chemical Properties

Amber crystalline powder

Uses

4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties.
Coupling Reagent for Trinder’s reagents in colorimetric hydrogen peroxide detectionassays
Forms highly stable dyes by coupling with Trinder’s reagents in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics.

Uses

Indicator for trace phenol determinations in water.

Uses

A reagent for glucose determination in the presence of peroxidase and phenol

Definition

ChEBI: A pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole.

Purification Methods

It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.]

4-Aminoantipyrine(83-07-8)Related Product Information

• Propyphenazone
• 4,4'-Diaminodiphenylsulfone
• N,N-Dimethylformamide
• Acetaminophen
• 4-Aminoantipyrine
• Antipyrine
• N-ACETYL-4-AMINOANTIPYRINE,Acetyl-4-aminoantipyrine,Acetylated 4-aminoantipyrine,Aminoantipyrine, N-acetyl-
• 2-CHLORO-N-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)ACETAMIDE
• ETHYL N-(4-ANTIPYRYL)CARBAMATE
• Dimethyl sebacate
• Dimethyl sulfoxide
• 4-DiMethylaMino Antipyrine
• Cefazolin sodium salt
• Cefazolin
• Chlorodimethylphenylsilane
• Dimethyl ether
• Dimethyl fumarate
• DMC