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4-Aminoantipyrine

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4-Aminoantipyrine Basic information

Product Name:
4-Aminoantipyrine
Synonyms:
  • Metamizole EP Impurity B
  • 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one
  • Metamizole Sodium Impurity 2(Minocycline EP Impurity B)
  • 4-aminoantipirine
  • 4-Amine-2,3-dimethyl-lphenyl-5-pyrazolone-[5],Ampyrone
  • 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on
  • AKOS BBS-00007964
  • AMINOANTIPYRINE
CAS:
83-07-8
MF:
C11H13N3O
MW:
203.24
EINECS:
201-452-3
Product Categories:
  • PYRAMIDON
  • Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • reagent
  • Drug bulk
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Antibiotic Explorer
  • Pharmaceuticals
Mol File:
83-07-8.mol
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4-Aminoantipyrine Chemical Properties

Melting point:
105-110 °C(lit.)
Boiling point:
340 C
Density 
0.8
refractive index 
1.4930 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: 0.1 g/mL, clear
pka
pK1: 4.94(+1) (25°C)
form 
Powder or Crystals
color 
Yellow to yellow-brown
Odor
Odorless
PH
7.1 (100g/l, H2O, 20℃)(slurry)
Water Solubility 
ca. 500 g/L (20 ºC)
Merck 
14,591
BRN 
181635
Stability:
Stable. May be light sensitive.
CAS DataBase Reference
83-07-8(CAS DataBase Reference)
NIST Chemistry Reference
Aminoantipyrene(83-07-8)
EPA Substance Registry System
4-Aminoantipyrene (83-07-8)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
26-36-36/37/39
WGK Germany 
3
RTECS 
CD2480000
8-9-23
Hazard Note 
Harmful
TSCA 
Yes
HS Code 
29331190
Toxicity
LD50 orally in Rabbit: 1700 mg/kg

MSDS

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4-Aminoantipyrine Usage And Synthesis

Chemical Properties

Amber crystalline powder

Uses

4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties.
Coupling Reagent for Trinder’s reagents in colorimetric hydrogen peroxide detectionassays
Forms highly stable dyes by coupling with Trinder’s reagents in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics.

Uses

Indicator for trace phenol determinations in water.

Uses

A reagent for glucose determination in the presence of peroxidase and phenol

Definition

ChEBI: A pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole.

Purification Methods

It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.]

4-AminoantipyrineSupplier

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