Basic information Description Chemical Properties Uses References Safety Supplier Related
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Dimethyl sulfate

Basic information Description Chemical Properties Uses References Safety Supplier Related

Dimethyl sulfate Basic information

Product Name:
Dimethyl sulfate
Synonyms:
  • DIMETHYLSULFATE,REAGENT
  • Dimethylsulfate,98%
  • DIMETHYL SULFATE 99 % MIN.
  • DIMETHYL SULFATE MOLECULAR BIOLOGY*REAGE NT
  • DIMETHYL SULFATE 99+%
  • Dimethylsulphate99%
  • DIMETHYL SULFATE[FOR ACETAMIPRID]
  • Dimethylsulfate (chemical production)
CAS:
77-78-1
MF:
C2H6O4S
MW:
126.13
EINECS:
201-058-1
Product Categories:
  • Pharmaceutical Intermediates
  • Miscellaneous Reagents, Sulfur & Selenium Compounds
  • 1
Mol File:
77-78-1.mol
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Dimethyl sulfate Chemical Properties

Melting point:
-32 °C
Boiling point:
188 °C(lit.)
Density 
1.333 g/mL at 25 °C(lit.)
vapor density 
4.3 (vs air)
vapor pressure 
0.7 mm Hg ( 25 °C)
refractive index 
n20/D 1.386(lit.)
Flash point:
182 °F
storage temp. 
2-8°C
solubility 
ethanol: 0.26 g/mL, clear, colorless
form 
Liquid
color 
Clear colorless
Odor
Almost odorless
Water Solubility 
2.8 g/100 mL (18 ºC)
Merck 
13,3282
BRN 
635994
Exposure limits
TLV/PEL-TWA skin 0.1 ppm (0.52 mg/m3 ) (ACGIH, OSHA, NIOSH) IDLH 10 ppm (NIOSH).
Stability:
Stable; combustible. Incompatible with strong oxidizing agents, strong bases including ammonia. Moisture-sensitive.
CAS DataBase Reference
77-78-1(CAS DataBase Reference)
IARC
2A (Vol. 4, Sup 7, 71) 1999
NIST Chemistry Reference
Sulfuric acid, dimethyl ester(77-78-1)
EPA Substance Registry System
Dimethyl sulfate (77-78-1)
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Safety Information

Hazard Codes 
T+
Risk Statements 
45-25-26-34-43-68
Safety Statements 
53-45-61
RIDADR 
UN 1595 6.1/PG 1
WGK Germany 
2
RTECS 
WS8225000
21
Autoignition Temperature
495 °C
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
29209090
Hazardous Substances Data
77-78-1(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 440 mg/kg (Smyth)
IDLA
7 ppm

MSDS

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Dimethyl sulfate Usage And Synthesis

Description

Dimethyl sulfate (chemical formula: (CH3O)2SO2) is an odorless, corrosive, oily liquid which can release toxic fumes during heating. It can be synthesized through the esterification of sulfuric acid with methanol, and alternatively by the distillation of methyl hydrogen sulfate.

In industry, dimethyl sulfate is used as a methylating agent for the manufacture of many organic chemicals. It can be used for methylation of phenols, amines, and thiol. Moreover, it can be used for base sequencing and DNA chain cleavage since it can rupture the imidazole rings present in guanine. It can also be used for protein-DNA interaction analysis. However, its vapor is toxic to eyes and lungs, can do harm to our body. It is a potential carcinogen based on known experimental data.

Chemical Properties

Dimethyl sulfate is a colorless, oily liquid that is slightly soluble in water. It has a faint, onion-like odor; the odor threshold has not been established. The vapor pressure for dimethyl sulfate is 0.5 mm Hg at 20 °C, and it has a log octanol/water partition coefficient (log Kow ) of 0.032.

Uses

Dimethyl sulphate has been used since the beginning of the century as a methylating agent in the preparation of organic chemical products and colouring agents, in the perfume industry, and in other processes. It is a colourless or yellowish liquid of oily consistency which vaporizes at 50℃. and has a slight piquant smell. Both the liquid and the vapour are vesicants and by virtue of this property may be used in warfare.

References

https://en.wikipedia.org/wiki/Dimethyl_sulfate
https://pubchem.ncbi.nlm.nih.gov/compound/dimethyl_sulfate#section=Top

Description

Dimethyl sulfate is a colorless, oily liquid with a faint, onionlike odor. It is soluble in water, ether, dioxane, acetone, benzene, and other aromatic hydrocarbons, miscible with ethanol, and sparingly soluble in carbon disulfide. It is stable under normal temperatures and pressures, but hydrolyzes rapidly in water at or above 18 ℃.
Dimethyl sulfate has been produced commercially since at least the 1920s. One production method is continuous reaction of dimethyl ether with sulfur trioxide. In 2009, dimethyl sulfate was produced by 33 manufacturers worldwide, including 1 in the United States, 14 in China, 5 in India, 5 in Europe, 6 in East Asia, and 2 in Mexico, and was available from 44 suppliers, including 16 US suppliers. There are no data on US imports or exports of dimethyl sulfate. Reports filed from 1986 through 2002 under the US Environmental Protection Agency’s Toxic Substances Control Act Inventory Update Rule indicate that US production plus imports of dimethyl sulfate totaled 10–50 million pounds. The simplest way of synthesizing dimethyl sulfate is by esterification of sulfuric acid with methanol as follows:2CH3OH+ H2SO4→(CH3)2SO4 + 2H2O

Chemical Properties

Dimethyl sulfate is essentially odorless. The specific gravity of this colorless, corrosive, oily liquid is 1.3322 g/cm3. Dimethyl sulfate is soluble in ether, dioxane, acetone, benzene, and other aromatic hydrocarbons. It is sparingly soluble in carbon disulfide and aliphatic hydrocarbons, and only slightly soluble in water (28 g/l at 18 °C) (O'Neil, 2006).

Uses

Dimethyl sulfate is a strong alkylating agent and might also react with the carboxylic acid substrate, further reducing the DMS concentration in the mixture. It is used as a methylating agent in themanufacture of many organic compounds,such as, phenols and thiols. Also, it is used inthe manufacture of dyes and perfumes, andas an intermediate for quaternary ammoniumsalts. It was used in the past as a militarypoison.

Application

Dimethyl Sulfate is a diester of methanol and sulfuric acid. Dimethyl Sulfate is commonly used as a reagent for the methylation of phenols, amines, and thiols. Dimethyl Sulfate is an effective and widely used probe for sequence-specific protein-DNA interactions.

Preparation

Dimethyl sulfate is prepared by distillation of an oleum/methanol mixture; technical production using dimethyl ether and SO3 has also been reported (NLM, 2013).

Definition

ChEBI: Dimethyl sulfate is the dimethyl ester of sulfuric acid. It has a role as an alkylating agent and an immunosuppressive agent.

General Description

Dimethyl sulfate is a colorless oily liquid, odorless to a faint onion-like odor. Dimethyl sulfate is very toxic by inhalation. Dimethyl sulfate is a combustible liquid and has a flash point of 182°F. Dimethyl sulfate is slightly soluble in water and decomposed by water to give sulfuric acid with evolution of heat. Dimethyl sulfate is corrosive to metals and tissue.

Air & Water Reactions

Water soluble.

Reactivity Profile

Pure Dimethyl sulfate and concentrated aqueous ammonia react extremely violently with one another, as is the case for tertiary organic bases, [NFPA 491M, 1991]. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. The product of methylating an unnamed material at 110°C was alloyed to remain in a reactor for 80 min. before the reactor exploded. This involved a sulfur ester such as Dimethyl sulfate, [MCA Case History No. 1786].

Health Hazard

Dimethyl sulfate is extremely hazardous because of its lack of warning properties and delayed toxic effects. The vapor of this compound is extremely irritating to the skin, eyes, and respiratory tract, and contact with the liquid can cause very severe burns to the eyes and skin. Ingestion of dimethyl sulfate causes burns to the mouth, throat, and gastrointestinal tract. The effects of overexposure to dimethyl sulfate vapor may be delayed. After a latent period of 10 hours or more, headache and severe pain to the eyes upon exposure to light may occur, followed by cough, tightness of the chest, shortness of breath, difficulty in swallowing and speaking, vomiting, diarrhea, and painful urination. Fatal pulmonary edema may develop. Systemic effects of dimethyl sulfate include damage to the liver and kidneys. Dimethyl sulfate is listed by IARC in Group 2A ("probable human carcinogen") and is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. Data indicate that dimethyl sulfate does not specifically harm unborn animals; dimethyl sulfate is not a developmental toxin. It is a strong alkylating agent and does produce genetic damage in animals and in bacterial and mammalian cell cultures.

Flammability and Explosibility

Dimethyl sulfate is a combustible liquid (NFPA rating = 2). Toxic dimethyl sulfate vapors are produced in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight dimethyl sulfate fires.

Carcinogenicity

Dimethyl sulfate is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

Chemical/Physical. Hydrolyzes in water (half-life = 1.2 h) to methanol and sulfuric acid (Robertson and Sugamori, 1966) via the intermediate methyl sulfuric acid (Du Pont, 1999a)

storage

work with dimethyl sulfate should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and safety goggles should be worn at all times to prevent skin and eye contact.

Incompatibilities

Dimethyl sulfate can react violently with ammonium hydroxide, sodium azide, and strong oxidizers.

Waste Disposal

Excess dimethyl sulfate and waste material containing this substance should be placed in a covered metal container, clearly labeled, and handled according to your institution's waste disposal guidelines.

Dimethyl sulfateSupplier

Zibo Yuanhui Chemical Co. LTD Gold
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13475537357
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380449826@qq.com
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Product Name:Dimethyl sulfate
CAS:77-78-1
Purity:98.5
Linyi yuanbo chemical co. LTD Gold
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13854961943
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13854961943@139.com
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Product Name:Dimethyl sulfate
CAS:77-78-1
Shanghai Song Yuan Chemical Technology Co., Ltd. Gold
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010-1234567 18521000990
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sonyuanchemical@163.com
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CAS:77-78-1
Purity:98%
Chengdu HuaNa Chemicals Co., Ltd. Gold
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13699069380
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515238037@qq.com
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Product Name:Dimethyl sulfate
CAS:77-78-1
Purity:98.0% Package:500g起,百公斤常备现货 Remarks:HY
Dalian Idery Biotechnology Co., Ltd. Gold
Tel
0411-62696576 15141125520
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dlidery@yeah.net
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Product Name:Dimethyl sulfate
CAS:77-78-1
Purity:99%+ Package:5kg