- Product Name:Dimethyl sulfate
- Synonyms: Glimepiride Impurity 32 Dimethylsulfate,98% DIMETHYL SULFATE 99 % MIN. DIMETHYL SULFATE MOLECULAR BIOLOGY*REAGE NT DIMETHYL SULFATE 99+% Dimethylsulphate99% DIMETHYLSULFATE,REAGENT DIMETHYL SULFATE[FOR ACETAMIPRID]
- Product Categories: Pharmaceutical Intermediates Miscellaneous Reagents, Sulfur & Selenium Compounds
- Mol File:77-78-1.mol
Dimethyl sulfate Chemical Properties
- Melting point:-32 °C
- Boiling point:188 °C(lit.)
- Density 1.333 g/mL at 25 °C(lit.)
- vapor density 4.3 (vs air)
- vapor pressure 0.7 mm Hg ( 25 °C)
- refractive index n20/D 1.386(lit.)
- Flash point:182 °F
- storage temp. 2-8°C
- solubility ethanol: 0.26 g/mL, clear, colorless
- form Liquid
- color Clear colorless
- OdorAlmost odorless
- Water Solubility 2.8 g/100 mL (18 ºC)
- Merck 13,3282
- BRN 635994
- Exposure limitsTLV/PEL-TWA skin 0.1 ppm (0.52 mg/m3 ) (ACGIH, OSHA, NIOSH) IDLH 10 ppm (NIOSH).
- Stability:Stable; combustible. Incompatible with strong oxidizing agents, strong bases including ammonia. Moisture-sensitive.
- CAS DataBase Reference77-78-1(CAS DataBase Reference)
- NIST Chemistry ReferenceSulfuric acid, dimethyl ester(77-78-1)
- EPA Substance Registry SystemSulfuric acid, dimethyl ester(77-78-1)
- Hazard Codes T+
- Risk Statements 45-25-26-34-43-68
- Safety Statements 53-45-61
- RIDADR UN 1595 6.1/PG 1
- WGK Germany 2
- RTECS WS8225000
- F 21
- Autoignition Temperature495 °C
- HazardClass 6.1(a)
- PackingGroup I
- HS Code 29209090
- Hazardous Substances Data77-78-1(Hazardous Substances Data)
- ToxicityLD50 orally in rats: 440 mg/kg (Smyth)
Dimethyl sulfate Usage And Synthesis
- DescriptionDimethyl sulfate (chemical formula: (CH3O)2SO2) is an odorless, corrosive, oily liquid which can release toxic fumes during heating. It can be synthesized through the esterification of sulfuric acid with methanol, and alternatively by the distillation of methyl hydrogen sulfate. In industry, dimethyl sulfate is used as a methylating agent for the manufacture of many organic chemicals. It can be used for methylation of phenols, amines, and thiol. Moreover, it can be used for base sequencing and DNA chain cleavage since it can rupture the imidazole rings present in guanine. It can also be used for protein-DNA interaction analysis. However, its vapor is toxic to eyes and lungs, can do harm to our body. It is a potential carcinogen based on known experimental data.
- Chemical Propertiescolourless liquid
- UsesDimethyl Sulfate is a diester of methanol and sulfuric acid. Dimethyl Sulfate is commonly used as a reagent for the methylation of phenols, amines, and thiols. Dimethyl Sulfate is an effective and widely used probe for sequence-specific protein-DNA interactions
- UsesMethylating agent in the manufacture of many organic chemicals. War gas.
- UsesDiethyl sulfate is used as an ethylating agentin many organic syntheses. It is also usedas an accelerator in the sulfation of ethyleneand as an intermediate in certain sulfonationreactions (Merck 1996).
- UsesIt is used as a methylating agent in themanufacture of many organic compounds,such as, phenols and thiols. Also, it is used inthe manufacture of dyes and perfumes, andas an intermediate for quaternary ammoniumsalts. It was used in the past as a militarypoison.
- DefinitionChEBI: The dimethyl ester of sulfuric acid.
- General DescriptionDimethyl sulfate is a colorless oily liquid, odorless to a faint onion-like odor. Dimethyl sulfate is very toxic by inhalation. Dimethyl sulfate is a combustible liquid and has a flash point of 182°F. Dimethyl sulfate is slightly soluble in water and decomposed by water to give sulfuric acid with evolution of heat. Dimethyl sulfate is corrosive to metals and tissue.
- Air & Water ReactionsWater soluble.
- Reactivity ProfilePure Dimethyl sulfate and concentrated aqueous ammonia react extremely violently with one another, as is the case for tertiary organic bases, [NFPA 491M, 1991]. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. The product of methylating an unnamed material at 110°C was alloyed to remain in a reactor for 80 min. before the reactor exploded. This involved a sulfur ester such as Dimethyl sulfate, [MCA Case History No. 1786].
- Health HazardDimethyl sulfate is extremely hazardous because of its lack of warning properties and delayed toxic effects. The vapor of this compound is extremely irritating to the skin, eyes, and respiratory tract, and contact with the liquid can cause very severe burns to the eyes and skin. Ingestion of dimethyl sulfate causes burns to the mouth, throat, and gastrointestinal tract. The effects of overexposure to dimethyl sulfate vapor may be delayed. After a latent period of 10 hours or more, headache and severe pain to the eyes upon exposure to light may occur, followed by cough, tightness of the chest, shortness of breath, difficulty in swallowing and speaking, vomiting, diarrhea, and painful urination. Fatal pulmonary edema may develop. Systemic effects of dimethyl sulfate include damage to the liver and kidneys. Dimethyl sulfate is listed by IARC in Group 2A ("probable human carcinogen") and is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. Data indicate that dimethyl sulfate does not specifically harm unborn animals; dimethyl sulfate is not a developmental toxin. It is a strong alkylating agent and does produce genetic damage in animals and in bacterial and mammalian cell cultures.
- Flammability and ExplosibilityDimethyl sulfate is a combustible liquid (NFPA rating = 2). Toxic dimethyl sulfate vapors are produced in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight dimethyl sulfate fires.
- Chemical ReactivityReactivity with Water Slow, non-hazardous reaction; Reactivity with Common Materials: Corrodes metal when wet; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Sodium bicarbonate or lime; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
- Safety ProfileConfirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human poison by inhalation. Experimental poison by ingestion, inhalation, intravenous, and subcutaneous routes. Other experimental reproductive effects. Human mutation datareported. A corrosive irritant to skin, eyes, and mucous membranes. There is no odor or initial irritation to give warning of exposure. On brief, dd exposures, conjunctivitis, catarrhal inflammation of the mucous membranes of the nose, throat, larynx, and trachea, and possibly some reddening of the skin develop after the latent period. With longer, heavier exposures, the cornea shows clouding, the irritation changes to the nasopharynx are more marked, and after 6 to 8 hours pulmonary edema may develop. Death may occur in 3 or 4 days. The liver and kidneys are frequently damaged. Spang of the liquid on the skin can cause ulceration and localnecrosis. In patients surviving severe exposure, there may be serious injury of the liver and hdneys, with suppression of urine, jaunlce, albuminuria, and hematuria appearing. Death, resulting from the hdney or liver damage, may be delayed for several weeks. Flammable when exposed to heat, flame, or oxidizers. Can react with oxidizing materials. Violent reaction with NH4OH and NaN3. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of SOx See also SULFATES.
- CarcinogenicityDimethyl sulfate is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
- Environmental FateChemical/Physical. Hydrolyzes in water (half-life = 1.2 h) to methanol and sulfuric acid (Robertson and Sugamori, 1966) via the intermediate methyl sulfuric acid (Du Pont, 1999a)
- storagework with dimethyl sulfate should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and safety goggles should be worn at all times to prevent skin and eye contact.
- IncompatibilitiesDimethyl sulfate can react violently with ammonium hydroxide, sodium azide, and strong oxidizers.
- Waste DisposalExcess dimethyl sulfate and waste material containing this substance should be placed in a covered metal container, clearly labeled, and handled according to your institution's waste disposal guidelines.
- RegulationsDepartment of Transportation (DOT)
Dimethyl sulfate is considered a hazardous material, and special requirements have been set for marking, labeling, and transporting this material.
Environmental Protection Agency (EPA)
Clean Air Act
National Emissions Standards for Hazardous Air Pollutants: Listed as a hazardous air pollutant.
New Source Performance Standards: Manufacture is subject to certain provisions for the control of volatile organic compound emissions.
Comprehensive Environmental Response, Compensation, and Liability Act
Reportable quantity (RQ) = 100 lb.
Emergency Planning and Community Right-To-Know Act
Toxics Release Inventory: Listed substance subject to reporting requirements.
Reportable quantity (RQ) = 100 lb.
Threshold planning quantity (TPQ) = 500 lb.
Resource Conservation and Recovery Act
Listed Hazardous Waste: Waste codes for which the listing is based wholly or partly on the presence of dimethyl sulfate = U103, K131. Listed as a hazardous constituent of waste.
Occupational Safety and Health Administration (OSHA)
While this section accurately identifies OSHA’s legally enforceable PELs for this substance in 2010, specific PELs may not reflect the more current studies and may not adequately protect workers. Permissible exposure limit (PEL) = 1 ppm (5 mg/3).
Dimethyl sulfate Preparation Products And Raw materials
- Preparation Products2,5-Dimethoxy-4-chloroaniline Aminophenazone5-Chloro-2-methoxybenzoic acido-Anisic acidα-Dimethoxymethyl-methoxypropionitrileMethyl cedryl etherantistatic Agent TM2,4,5-Trimethoxynitrobenzene 4-METHYLDIBENZOTHIOPHENE2,4-Dimethoxybenzoic acidMethyl trifluoromethanesulfonate6-AMINO-2-METHYLTHIO-3-METHYLURACIL3,5-DIBROMO-2-METHOXYBENZALDEHYDEFursultiamine5-Chloro-2-(methylamino)benzophenone3-(Dimethylamino)benzoic acid7-METHYLGUANINE2-(4-aminophenyl)propiononitrileMethyl 4-acetamido-2-methoxybenzoate1-CHLOROMETHYL-2,3,4-TRIMETHOXYBENZENEOxybenzone5-(Dimethylamino)-1-naphthalenesulfonic acid7-METHOXY-3,4,5,6-TETRAHYDRO-2H-AZEPINE3'-DIMETHYLAMINOACETOPHENONEBIFENAZATE2-(4-(ACETYLAMINO)PHENYL)PROPIONITRILECationic surface active agent3,5-Dimethoxybenzoic acidMethyl 4-acetamido-5-chloro-2-methoxybenzoatesoftening CS1-METHYL-5-NITROIMIDAZOLE2-(4-ACETAMINO-3-CHLOROPHENYL)PROPIONITRILE3,4-DIHYDROXY-5-METHOXYBENZOIC ACID METHYL ESTERtrimethyl lauroylaminopropyl ammonium methylsulfateSCOPARONE3,4,5-TRIMETHOXYBENZHYDRAZIDE2-(METHYLTHIO)BENZOIC ACIDBENZOIC 2-BENZOYL-1,2-DIMETHYLHYDRAZIDE2-(4-Nitrophenyl)propiononitrileCationic Brilliant Blue RL
- Raw materialsMethanolSulfuric acid SULFURIC ACIDSulfurChlorosulfonic acidNicotinic acidSulfur trioxideOLEU
- Phenazine methosulfate Colistin sulfate Dimethyl ether ETHANE Magnesium sulfate heptahydrate Ammonium sulfate Ferric sulfate Dimethyl phthalate Dimethyl sulfoxide Dimethyl sebacate Potassium sulfate sulfate Ferrous sulfate monohydrate Methyl Sodium sulfate N,N-Dimethylformamide Dimethyl carbonate Albuterol sulfate
- Company Name:Shanghai Song Yuan Chemical Technology Co., Ltd. Gold
- Products Intro:CAS:77-78-1
- Company Name:Nanjing Huang Tai Pharmaceutical Technology Co. Ltd. Gold
- Products Intro:Product Name:Dimethyl sulfate
- Company Name:Shanghai Kangman Biological Technology Co., Ltd. Gold
- Tel: 18800375331
- Products Intro:CAS:77-78-1
Purity:98% HPLC Package:25g,100g,500g,1kg,5kg,25kg
- Company Name:Chengdu HuaNa Chemicals Co., Ltd. Gold
- Tel:028-86612776 13699069380
- Products Intro:CAS:77-78-1
- Company Name:Shandong Ono Chemical Co., Ltd. Gold
- Tel:0539-6362799（To 20）
- Products Intro:CAS:77-78-1