SCOPARONE
SCOPARONE Basic information
- Product Name:
- SCOPARONE
- Synonyms:
-
- Scoparone 120-08-1
- 6,7-dihydroxy-3,4-dimethyl-1-benzopyran-2-one
- 6,7-dimethoxy-coumari
- 6,7-Dimethoxycoumarine
- aesculetindimethylether
- escoparone
- scoparon
- 6,7-DIMETHOXY-CHROMEN-2-ONE
- CAS:
- 120-08-1
- MF:
- C11H10O4
- MW:
- 206.19
- EINECS:
- 204-369-0
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Inhibitors
- Coumarins
- API intermediates
- Mol File:
- 120-08-1.mol
SCOPARONE Chemical Properties
- Melting point:
- 143-145 °C (lit.)
- Boiling point:
- 265.04°C (rough estimate)
- Density
- 1.0858 (rough estimate)
- refractive index
- 1.4389 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- >8.4mg/mL in DMSO
- form
- Powder
- color
- Light yellow to yellow
- Merck
- 13,8479
- LogP
- 1.331 (est)
- CAS DataBase Reference
- 120-08-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 2H-1-benzopyran-2-one, 6,7-dimethoxy-(120-08-1)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 23/24/25-36-22
- Safety Statements
- 27/28-36/37/39-45-26
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- GN6550000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29322090
SCOPARONE Usage And Synthesis
Uses
Scoparone-13C2D6 is a by-product in the synthesis of Scopoletin-13C,d3 (S200502). Scopoletin-13C,d3, is the labeled analogue of Scopoletin (S200500), used for cosmetics, topical formulations, and foods. Scoparone-13C2D6 is also the labeled form of Scoparone (S199980), which regulates the expression of Th1/Th2 cytokines and IgE and is effective in treating allergic rhinitis.
Definition
ChEBI: Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities. It has a role as a plant metabolite, an anti-inflammatory agent, an antilipemic drug, an immunosuppressive agent, an antihypertensive agent and an anti-allergic agent. It is a member of coumarins and an aromatic ether. It is functionally related to an esculetin.
Synthesis Reference(s)
Synthesis, p. 1026, 1986 DOI: 10.1055/s-1986-31859
General Description
6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported.
Safety Profile
Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. An anthypertensive agent. When heated to decomposition it emits acrid smoke and irritating fumes.
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SCOPARONE(120-08-1)Related Product Information
- 6,7-Diethoxy-4-(trifluoromethyl)coumarin
- 6,7-DIMETHOXY-4-METHYLCOUMARIN
- 6,7,8-TRIMETHOXYCOUMARIN
- ESCULETIN DIBENZYL ETHER
- Oxamarin
- 8-ACETYL DIMETHOXYCOUMARIN
- SCOPARONE
- 4-BROMOMETHYL-6,7-DIMETHOXYCOUMARIN
- FRAXIDIN
- 5,7-Dimethoxycoumarin
- Dimethyl ether
- Coumarin
- Esculetin
- 6,7-DIMETHOXY-4-ETHYLCOUMARIN
- 6,7-DIACETOXY-4-METHYLCOUMARIN
- scopolin
- 6,7-DIMETHOXY-4-(TRIFLUOROMETHYL)COUMARIN
- 6,7-DIMETHOXYCOUMARIN-4-ACETIC ACID