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Nimesulide

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Nimesulide Basic information

Product Name:
Nimesulide
Synonyms:
  • nimed
  • 4-NITRO-2-PHENOXYMETHANE SULPHONANILIDE
  • CETIRIZINE DIHYDROCHLORIDE EPC(CRM STANDARD)
  • CETIRIZINE DIHYDROCHLORIDE IMP. E (EP):(RS)-2-[2-[2-[4-[(4-CHLOROPHENYL)-PHENYLMETHYL]PIPERAZIN-1-YL]ETHOXY]ETHOXY]ACETIC ACID MM(CRM STANDARD)
  • CETIRIZINE DIHYDROCHLORIDE MM(CRM STANDARD)
  • 4-Nitro-2-phenoxymethanesulfonamide
  • Nide
  • Nidol
CAS:
51803-78-2
MF:
C13H12N2O5S
MW:
308.31
EINECS:
257-431-4
Product Categories:
  • All Inhibitors
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Active Pharmaceutical Ingredients
  • Aromatics
  • Isotope Labelled Compounds
  • Sulfur & Selenium Compounds
  • Other APIs
Mol File:
51803-78-2.mol
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Nimesulide Chemical Properties

Melting point:
140-146°C
Boiling point:
442.0±55.0 °C(Predicted)
Density 
1.451±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.
pka
pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
form 
neat
Water Solubility 
Soluble in water (<50 &#181;g/ml), 1:10 DMSO:PBS (pH 7.2) (<200 &#181;g/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
λmax
391nm(H2O)(lit.)
Merck 
14,6548
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
HYWYRSMBCFDLJT-UHFFFAOYSA-N
CAS DataBase Reference
51803-78-2(CAS DataBase Reference)
EPA Substance Registry System
Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- (51803-78-2)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-26
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
PB0970000
HazardClass 
6.1
PackingGroup 
III
Toxicity
LD50 orally in rats: 324 mg/kg (Swingle, Moore)

MSDS

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Nimesulide Usage And Synthesis

Description

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is indicated for the treatment of acute pain, symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults. However, due to the risk of causing hepatotoxicity, it should not be taken long-term. It has also been withdrawn from the markets in many countries. It mechanism of action is through targeting on various key mediators in the inflammatory process such as COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.

Chemical Properties

Yellow Needle-Like Crystals

Originator

Riker (USA)

Uses

Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production

Uses

Labelled Nimesulide (N477500). Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.

Uses

Antiinflammatory;'Cyclooxygenase 2 inhibitor

Uses

For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.

Uses

Labelled Nimesulide . Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.;Labeled Nimesulide, intended for use as an internal standard for th

Uses

Nimesulide is a selective inhibitor of COX-2. The IC50 values are 70 and 1.27 μM for human recombinant COX-1 and -2 (at 20 μM arachidonic acid), respectively, and 22 and 0.03 μM for ovine COX-1 and -2 (at 100 μM arachidonic acid), respectively.[Cayman Chemical]

brand name

Nimulid.

Biological Activity

Selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo . Reported to produce fewer gastrointestinal side effects than standard NSAIDs.牋.

Clinical Use

Nimesulide is a nonsteroidal antiinflammatory/analgesic agent useful in the treatment of rheumatoid arthritis, as well as acute inflammation such as that induced by periodontal surgery or urinary tract infections.

References

https://en.wikipedia.org/wiki/Nimesulide
https://www.drugbank.ca/drugs/DB04743

Nimesulide Preparation Products And Raw materials

Raw materials

NimesulideSupplier

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