2-Methylbenzene-1-sulfonamide Chemical Properties

Melting point:

156-158 °C (lit.)

Boiling point:

221 °C

Density 

1.2495 (rough estimate)

vapor pressure 

0-0.008Pa at 25℃

refractive index 

1.6100 (estimate)

Flash point:

178°C

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Very Slightly, Heated)

pka

10.17±0.60(Predicted)

color 

White to Off-White

Water Solubility 

Soluble in water (1.6 g/L at 25°C).

BRN 

1102362

InChIKey

YCMLQMDWSXFTIF-UHFFFAOYSA-N

LogP

0.6-0.9 at 20-25℃

CAS DataBase Reference

88-19-7(CAS DataBase Reference)

NIST Chemistry Reference

Benzenesulfonamide, 2-methyl-(88-19-7)

EPA Substance Registry System

Benzenesulfonamide, 2-methyl- (88-19-7)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36-40

Safety Statements 

26-36/37

WGK Germany 

1

RTECS 

XT5075000

TSCA 

Yes

HS Code 

29350090

Hazardous Substances Data

88-19-7(Hazardous Substances Data)

MSDS

• Language:English Provider:2-Methylbenzene-1-sulfonamide
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
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2-Methylbenzene-1-sulfonamide Usage And Synthesis

Chemical Properties

2-Methylbenzene-1-sulfonamide is Colorless crystals. Soluble in alcohol; slightly soluble in water and ether. Combustible.

Uses

Plasticizer of thermosetting resin, as a raw material used in organic synthesis, preparation of nail polish, dyes, fluorescent pigments and coatings.

Uses

2-Methylbenzene-1-sulfonamide is a methylated sulfonamide and a major Impurity if Saccharin (S080800). Studies suggest that o-Toluenesulfonamide has potential mutagenic activity.

Uses

o-Toluenesulfonamide is a methylated sulfonamide and a major impurity if Saccharin (S080800). Studies suggest that o-Toluenesulfonamide has potential mutagenic activity.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. o-Toluenesulfonamide is a major impurity in artificial sweetening substances containing saccharin.

Safety Profile

Suspected carcinogen with experimental tumorigenic data. Mildly toxic by ingestion. Experimental reproductive effects. Mutation data reported. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx. Used as a chemical intermediate in the production of saccharin.

Purification Methods

Crystallise the amide from hot H2O (m 153o), then from EtOH or Et2O/pet ether. The N-o-toluenesulfonylphthalimide has m 182o (from EtOH). [Evans & Dehn J Am Chem Soc 51 3652 1929, Beilstein 11 H 86, 11 I 23, 11 II 39, 11 III 167, 11 IV 229.]

2-Methylbenzene-1-sulfonamide(88-19-7)Related Product Information

• 2-Nitrotoluene
• N-Fluorobenzenesulfonimide
• Trifluoromethanesulfonamide
• 4-Nitrotoluene-2-sulfonic Acid
• O-TOLUENESULFONYL CHLORIDE
• o-Xylene
• 2-Chlorotoluene
• N-n-Butyl benzene sulfonamide
• 2-Bromotoluene
• 2-Carbomethoxybenzenesulfonamide
• Methanesulfonamide
• Sulfanilamide
• Benzenesulfonamide
• 2-Toluenesulfonyl isocyanate
• 2-Chlorophenyl isocyanate
• 2-Methylphenylacetic acid
• 2'-Hydroxyacetophenone
• 2-Methylbenzyl cyanide