Methanesulfonamide Chemical Properties

Melting point:

85-89 °C(lit.)

Boiling point:

208.2±23.0 °C(Predicted)

Density 

1.229 (estimate)

refractive index 

1.5130 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Slightly soluble in DMSO and methanol.

pka

10.87±0.60(Predicted)

form 

Crystals, Powder or Flakes

color 

White to yellow

BRN 

1740835

InChIKey

HNQIVZYLYMDVSB-UHFFFAOYSA-N

CAS DataBase Reference

3144-09-0(CAS DataBase Reference)

NIST Chemistry Reference

Methane sulfonamide(3144-09-0)

EPA Substance Registry System

Methanesulfonamide (3144-09-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25

WGK Germany 

3

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29350090

MSDS

• Language:English Provider:Methanesulfonamide
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Methanesulfonamide Usage And Synthesis

Chemical Properties

White to yellow crystals, powder or flakes

Uses

Methanesulfonamide will react with thionyl chloride, cyanates, carbon disulfide and ketones and aldehydes to prepare pharmaceuticals, brightening agent and other target molecules. It is also used in biological studies to predict binding affinity and binding mode of protein ligand complexes.

Uses

• Methanesulfonamide is used in the synthesis of important organic reagents such as N-(2-methylthio-1-p-toluenesufonyl)methanesulfonamide and tert-butyl ((2-(trimethylsilyl)ethyl)sulfonyl)carbamate.
• It can be used as a source of nitrogen in the conversion of carboxylic acids to corresponding nitriles.
• It is widely used as a reagent in the synthesis of medicinally important compounds such as derivatives of indole-N-acetamide, methanesulfonamide pyrimidine-substituted 3,5-dihydroxy-6-heptenoates and repertaxin.

Synthesis Reference(s)

Journal of the American Chemical Society, 90, p. 4096, 1968 DOI: 10.1021/ja01017a032
The Journal of Organic Chemistry, 60, p. 7682, 1995 DOI: 10.1021/jo00128a048
Tetrahedron Letters, 35, p. 7201, 1994 DOI: 10.1016/0040-4039(94)85360-6

Methanesulfonamide(3144-09-0)Related Product Information

• 3-Aminobenzenesulfonamide
• Cyclopropanesulfonamide
• TRIFLUOROMETHANESULFONYL FLUORIDE
• Trifluoromethanesulfonamide
• Sulfamide
• Dimethyl sulfone
• Sodium carboxymethyl cellulose
• N,N-Dimethylformamide
• Sulfanilamide
• Benzenesulfonamide
• p-Toluenesulfonamide
• Ethanesulfonamide
• DANSYL HYDRAZINE
• N-Phenyl-bis(trifluoromethanesulfonimide)
• ACID VIOLET 5
• TPCK
• 4-AMINOSULFONYL-1-HYDROXY-2-NAPHTHOIC ACID, 97
• p-Toluenesulfonyl Isocyanate