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Methanesulfonamide

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Methanesulfonamide Basic information

Product Name:
Methanesulfonamide
Synonyms:
  • Methylsulfonamid
  • METHYL SULFONYLAMINE
  • METHYL SULFONAMIDE
  • LABOTEST-BB LT00153664
  • Methanesulfonamide, 98+%
  • Methanesulphonamide,98+%
  • Mesyl amide
  • Methanesulfonyl amide
CAS:
3144-09-0
MF:
CH5NO2S
MW:
95.12
EINECS:
221-553-6
Product Categories:
  • Pharmaceutical Intermediates
Mol File:
3144-09-0.mol
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Methanesulfonamide Chemical Properties

Melting point:
85-89 °C(lit.)
Boiling point:
208.2±23.0 °C(Predicted)
Density 
1.229 (estimate)
refractive index 
1.5130 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Slightly soluble in DMSO and methanol.
pka
10.87±0.60(Predicted)
form 
Crystals, Powder or Flakes
color 
White to yellow
BRN 
1740835
InChIKey
HNQIVZYLYMDVSB-UHFFFAOYSA-N
CAS DataBase Reference
3144-09-0(CAS DataBase Reference)
NIST Chemistry Reference
Methane sulfonamide(3144-09-0)
EPA Substance Registry System
Methanesulfonamide (3144-09-0)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29350090

MSDS

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Methanesulfonamide Usage And Synthesis

Chemical Properties

White to yellow crystals, powder or flakes

Uses

Methanesulfonamide will react with thionyl chloride, cyanates, carbon disulfide and ketones and aldehydes to prepare pharmaceuticals, brightening agent and other target molecules. It is also used in biological studies to predict binding affinity and binding mode of protein ligand complexes.

Uses

  • Methanesulfonamide is used in the synthesis of important organic reagents such as N-(2-methylthio-1-p-toluenesufonyl)methanesulfonamide and tert-butyl ((2-(trimethylsilyl)ethyl)sulfonyl)carbamate.
  • It can be used as a source of nitrogen in the conversion of carboxylic acids to corresponding nitriles.
  • It is widely used as a reagent in the synthesis of medicinally important compounds such as derivatives of indole-N-acetamide, methanesulfonamide pyrimidine-substituted 3,5-dihydroxy-6-heptenoates and repertaxin.

Synthesis Reference(s)

Journal of the American Chemical Society, 90, p. 4096, 1968 DOI: 10.1021/ja01017a032
The Journal of Organic Chemistry, 60, p. 7682, 1995 DOI: 10.1021/jo00128a048
Tetrahedron Letters, 35, p. 7201, 1994 DOI: 10.1016/0040-4039(94)85360-6

Methanesulfonamide Preparation Products And Raw materials

Preparation Products

Raw materials

MethanesulfonamideSupplier

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