ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > BMS 663068 (Tris)
BMS 663068 (Tris)
BMS 663068 (Tris) Basic information
- Product Name:
- BMS 663068 (Tris)
- Synonyms:
-
- BMS663068 (TRIS); BMS 663068 (TRIS)
- Fostemsavir Tris
- BMS 663068 (Tris)
- BMS663068 (Tris)
- BMS-663068 (Tris)
- Fostemsavir tromethamine
- Fostemsavir Tris (BMS-663068 Tris)
- Fostemsavir Tris (BMS-663068 trisaminomethane)
- CAS:
- 864953-39-9
- MF:
- C29H37N8O11P
- MW:
- 704.624841
- Mol File:
- 864953-39-9.mol
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BMS 663068 (Tris) Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO : 125 mg/mL (177.40 mM; Need ultrasonic)
- form
- Powder
- color
- White to off-white
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BMS 663068 (Tris) Usage And Synthesis
Uses
Fostemsavir Tris (BMS-663068 (Tris)) is the phosphonooxymethyl proagent of BMS-626529. Fostemsavir Tris (BMS-663068 (Tris)) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells.
in vivo
Fostemsavir Tris has good antiviral activity in subjects infected with virus shown to be susceptible (IC50, <100 nM) to the agent[1].
IC 50
HIV-1
References
[1] Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507. DOI:10.1128/AAC.00426-12
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