(6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one Chemical Properties

Boiling point:

477.5±45.0 °C(Predicted)

Density 

1.10±0.1 g/cm3(Predicted)

pka

2.97±0.60(Predicted)

InChIKey

AIVVBBARCYSYDU-SIKLNZKXSA-N

SMILES

C12[C@H](O[Si](C(C)C)(C(C)C)C(C)C)CC[C@@H](C3=CC=CC(F)=C3F)C(=O)C1=CC=CN=2

(6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one Usage And Synthesis

Uses

(6S,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-9-[[triisopropylsilyl]oxy]-5H-cycloheptatrien[B]pyridin-5-one is a pharmaceutical chemical intermediate that can be used in the production of the drug molecule Remegapan.

Chemical Properties

(6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[triisopropylsilyl]oxy]-5H-cycloheptatrieno[B]pyridin-5-one is a cycloheptanone-pyridinium organic compound with a reactive hydroxyl reactive group protected by a silyl unit in its structure, which can be hydrolyzed to remove the silyl protecting group under acidic conditions. In addition, its structure contains a carbonyl α-carbon atom chiral center, which is sensitive to alkalis and is prone to undergo enolic reciprocal isomerism under the action of bases leading to the disappearance of its chirality.

(6S,9R)-6-(2,3-Difluorophenyl)-6,7,8,9-tetrahydro-9-[[tris(1-methylethyl)silyl]oxy]-5H-cyclohepta[b]pyridin-5-one(1190363-46-2)Related Product Information

• (R)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-onehydrochloride
• 2-Chloro-4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidine
• 1-(1-(1H-imidazole-1-carbonyl)piperidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
• MK-4618 Pyrimidinone Acid Sodium Salt
• ((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone