OTS964 Chemical Properties

storage temp. 

Store at -20°C

solubility 

≥88.6 mg/mL in DMSO; ≥2.15 mg/mL in EtOH with gentle warming and ultrasonic; ≥2.1 mg/mL in H2O with gentle warming and ultrasonic

form 

crystalline solid

color 

Off-white to light yellow

Safety Information

HS Code 

2934999090

OTS964 Usage And Synthesis

Description

OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC₅₀ = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells. OTS964 induces apoptosis of human lung cancer cells in mouse xenografts.

Uses

OTS 964 works through cytokinesis and is an effective TOPK inhibitor which has been shown to cause tumor suppression in xenografts of human cancer.

References

1. matsuo y, park jh2, miyamoto t, et al. topk inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. ci transl med. 2014 oct 22;6(259):259ra145.

OTS964(1338545-07-5)Related Product Information

• CP 31398
• Olaparib
• CP-31398 Dihydrochloride Hydrate