N-BENZYLOXYCARBONYL-4-PIPERIDINESULFONYL CHLORIDE Chemical Properties

Boiling point:

454.9±44.0 °C(Predicted)

Density 

1.39±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-3.77±0.40(Predicted)

form 

powder

color 

Light beige/beige

CAS DataBase Reference

287953-54-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

43

Safety Statements 

36/37

Hazard Note 

Corrosive

HS Code 

2933399990

N-BENZYLOXYCARBONYL-4-PIPERIDINESULFONYL CHLORIDE Usage And Synthesis

Synthesis

General procedure for the synthesis of N-Benzyloxycarbonyl-4-piperidinesulfonyl chloride from benzyl 4-(acetylthio)piperidine-1-carboxylate: Benzyl 4-(acetylthio)piperidine-1-carboxylate (1.45 g, 4.94 mmol) was dissolved in a mixed solvent of dichloromethane (10 mL) and water (40 mL), and the reaction was stirred for 4 hours at 0 °C, while chlorine was passed through the reaction. After completion of the reaction, the organic layer was separated and the aqueous layer was extracted with dichloromethane. The organic layers were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent to afford benzyl 4-(chlorosulfonyl)-1-piperidinecarboxylate (1.58 g, 100% yield).

References

[1] Patent: EP1403255, 2004, A1. Location in patent: Page 90
[2] Synthesis, 2011, # 22, p. 3669 - 3674
[3] Patent: WO2003/103669, 2003, A1. Location in patent: Page 44-45

N-BENZYLOXYCARBONYL-4-PIPERIDINESULFONYL CHLORIDE(287953-54-2)Related Product Information

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