HNE
HNE Basic information
- Product Name:
- HNE
- Synonyms:
-
- Ccris 1781
- (E)-4-HYDROXYNONENAL
- HNE
- 4-HYDROXY-2-NONENAL
- 4-HNE
- (+/-)-4-HYDROXY-2E-NONENAL
- (+/-)-4-HYDROXYNON-2-ENAL
- 4-HYDROXYNONENAL
- CAS:
- 75899-68-2
- MF:
- C9H16O2
- MW:
- 156.22
- Mol File:
- 75899-68-2.mol
HNE Chemical Properties
- Boiling point:
- 125-127 °C(Press: 2 Torr)
- Density
- 0.941±0.06 g/cm3(Predicted)
- storage temp.
- -70°C
- solubility
- DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1 mg/ml
- pka
- 13.31±0.20(Predicted)
- form
- Colorless oil.
- color
- Colorless to light yellow
- InChI
- InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
- InChIKey
- JVJFIQYAHPMBBX-FNORWQNLSA-N
- SMILES
- C(=O)/C=C/C(O)CCCCC
- CAS DataBase Reference
- 75899-68-2(CAS DataBase Reference)
HNE Usage And Synthesis
Uses
4-Hydroxynonenal is an irreversible inhibitor of Na+/K+-ATPase activity.
Uses
HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid. 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation. It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. HNE inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 μM.[Cayman Chemical]
Definition
ChEBI: 4-hydroxynon-2-enal is an enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position. It has a role as a human metabolite. It is a hydroxyaldehyde, an enal and a 4-hydroxynonenal.
Biological Activity
Primary Target
Na+, K+-ATPase activity', 'Product does not compete with ATP.', 'Target IC50: 120 μM against Na+, K+-ATPase activity
in vivo
Following 24 h after fluid percussion injury (FPI), the mouse brain tissue is analyzed for the expression level of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), 4-Hydroxynonenal (4-HNE. Both wild-type (Nrf2+/+) and Nrf2-deficient mice (Nrf2-/-) results in increased expression of 4-Hydroxynonenal following 15 psi injury (moderate injury) when compared to uninjured Nrf2+/+ and Nrf2-/- mice. Similar to iNOS result, in Nrf2-/- KO mice, the expression level of 4-Hydroxynonenal is significantly high when compared to corresponding injured and uninjured Nrf2+/+ WT animals[2].
IC 50
ALDH2; Human Endogenous Metabolite
HNESupplier
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HNE(75899-68-2)Related Product Information
- Titanium tetrachloride
- Glutathione
- 4-hydroxy Nonenal-d3
- (E)-4-HYDROXY-2-NONENAL,TRANS-4-HYDROXY-2-NONENAL
- TRANS-4-HYDROXY-2-NONENAL-5,5,6,6,7,7,8,8,9,9,9-D11 DIMETHYL ACETAL
- (E)-4-HYDROXYNONENAL-DIMETHYLACETAL,(E)-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA,(E)-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA,HNE-DA,HNE-DMA
- (E)-4-HYDROXYNONENAL, >85%
- HNE INHIBITOR
- ANTI-HNE FLUOROPHORE
- TAC, CD70, CD27 Ligand, Clone: HNE.51, Mab anti-Human, FITC
- ANTI-HNE PAB,ANTISERUM TO (E)-4-HYDROXYNONENAL
- 4-Hydroxynonenal conj. BSA Purified
- ANTI-(E)-4-HYDROXYNONENAL,ANTI-HNE,ANTI-4-HYDROXY-2-NONENAL
- 4R-HYDROXY-2-NONENAL
- ANTI-HNE-MICHAEL ADDUCTS, REDUCED,ANTI-HNE-MICHAEL ADDUCTS, REDUCED (RABBIT),ANTI-HNE-MICHAEL ADDUCTS, REDUCED RABBIT PAB
- 4S-HYDROXY-2-NONENAL
- TAC, CD70, CD27 Ligand, Clone: HNE.51, Mab anti-Human
- HNE (4-Hydroxy-2-nonenal),HNE (4-Hydroxy-2-nonenal)