PROTEASOME SUBSTRATE VI, FLUOROGENIC Chemical Properties

Density 

1.41±0.1 g/cm3(Predicted)

storage temp. 

-15°C

solubility 

DMSO: 200mg/mL
80% acetic acid: 50mg/mL
methanol: soluble

form 

solid

pka

11.13±0.46(Predicted)

color 

white to off-white

PROTEASOME SUBSTRATE VI, FLUOROGENIC Usage And Synthesis

Uses

Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome[1].

Biological Activity

Cell permeable: no', 'Primary Target
Proteasome', 'Product does not compete with ATP.', 'Reversible: no

References

[1] Crawford LJ, et al. Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132. Cancer Res. 2006 Jun 15;66(12):6379-86. DOI:10.1158/0008-5472.CAN-06-0605

PROTEASOME SUBSTRATE VI, FLUOROGENIC(90468-18-1)Related Product Information

• Z-ALA-ALA-LEU-PNA
• Z-ALA-ALA-ASN-AMC
• RHODAMINE 110, BIS-(CBZ-L-ALANYL-L-ALANYL-L-ALANYL-L-ALANINE AMIDE)
• L-ARGININE 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE
• Z-ALA-ARG-ARG-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN
• Z-GLY-GLY-ARG-7-AMINO-4-METHYLCOUMARIN
• PROTEASOME SUBSTRATE VI, FLUOROGENIC