Z-ALA-ALA-ASN-AMC
Z-ALA-ALA-ASN-AMC Basic information
- Product Name:
- Z-ALA-ALA-ASN-AMC
- Synonyms:
-
- BENZYLOXYCARBONYL-L-ALANYL-L-ALANYL-L-ASPARAGINE 4-METHYLCOUMARYL-7-AMIDE
- Z-AAN-AMC
- Z-ALA-ALA-ASN-AMC
- Z-ALA-ALA-ASN-MCA
- L-Aspartamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-L-alanyl-N1-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
- Benzyl ((S)-1-(((S)-1-(((S)-4-amino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1,4-dioxobutan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)carbamate
- CAS:
- 149697-16-5
- MF:
- C28H31N5O8
- MW:
- 565.57
- Product Categories:
-
- peptide
- Mol File:
- 149697-16-5.mol
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Z-ALA-ALA-ASN-AMC Chemical Properties
- Boiling point:
- 984.1±65.0 °C(Predicted)
- Density
- 1.346±0.06 g/cm3(Predicted)
- storage temp.
- -15°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 11.14±0.46(Predicted)
- color
- White to off-white
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Z-ALA-ALA-ASN-AMC Usage And Synthesis
Uses
Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC[1].
References
[1] Stern L, Perry R, Ofek P, Many A, Shabat D, Satchi-Fainaro R. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug Chem. 2009;20(3):500-510. DOI:10.1021/bc800448u
[2] James C. Powers, et al. Propenoyl hydrazides. US7482379B2.
[3] Poreba M, et al. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chem Biol. 2016;23(8):1023-1035. DOI:10.1016/j.chembiol.2016.05.020
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