Basic information Safety Supplier Related

LDN-212320

Basic information Safety Supplier Related

LDN-212320 Basic information

Product Name:
LDN-212320
Synonyms:
  • LDN-212320
  • LDN-0212320
  • 3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine
  • (3-[(2-methylbenzyl)sulfenyl]-6-(pyridine-2-yl)pyridazine)
  • LDN/OSU-0212320
  • LDN/OSU-0212320;LDN-0212320;OSU-0212320
  • OSU-0212320
  • 3-((2-methylbenzyl)thio)-6-(pyridin-2-yl)pyridazine
CAS:
894002-50-7
MF:
C17H15N3S
MW:
293.39
Mol File:
894002-50-7.mol
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LDN-212320 Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (170.42 mM; Need ultrasonic)
form 
Powder
color 
White to gray
InChI
InChI=1S/C17H15N3S/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15/h2-11H,12H2,1H3
InChIKey
DUUQLWDHNYFUPP-UHFFFAOYSA-N
SMILES
C1(SCC2=CC=CC=C2C)=NN=C(C2=NC=CC=C2)C=C1
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LDN-212320 Usage And Synthesis

Uses

LDN 212320 is a small molecule activator of glutamate transporter EAAT2 translation, which provides neuroprotection and shows potential for the therapeutic treatment of neurodegenerative diseases.

in vivo

LDN-212320 (10 or 20 mg/kg, i.p) significantly attenuates formalin-evoked nociceptive behavior[1].
LDN-212320 (10 or 20 mg/kg, i.p) significantly reverses formalin-induced impaired hippocampal-dependent behavior. In addition, LDN-212320 (10 or 20 mg/kg, i.p) increases GLT-1 expressions in the hippocampus and ACC[1].
LDN-212320 (20 mg/kg, i.p) significantly reduced formalin induced-ERK phosphorylation, a marker of nociception, in the hippocampus and ACC[1].

Animal Model:Mice[1].
Dosage:10 or 20 mg/kg.
Administration:IP 24 h before the injection of formalin.
Result:Significantly attenuated licking and biting behavior during both phases 1 and 2 in a dose-dependent manner compared to formalin-injected mice.
Significantly (P < 0.01 or P < 0.001) reduced the licking and biting behavior.
Significantly increased preference for the displaced object (F3, 13 = 28.03, P < 0.01) compared to formalin-injected mice.
Significantly (P < 0.001) increased interaction time with the displaced object compared to formalin-injected mice.

IC 50

EAAT2

LDN-212320Supplier

ChemeGen(Shanghai) Biotechnology Co.,Ltd. Gold
Tel
18818260767
Email
sales@chemegen.com
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Email
sales@pharmacodia.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Email
505721671@qq.com
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LDN-212320(894002-50-7)Related Product Information