DIFETHIALONE Chemical Properties

Melting point:

203-227°

Boiling point:

658.3±55.0 °C(Predicted)

Density 

1.3614 g/cm3(Temp: 25 °C)

solubility 

Chloroform: slightly soluble; Methanol: slightly soluble

form 

A solid

pka

4.50±1.00(Predicted)

EPA Substance Registry System

Difethialone (104653-34-1)

Safety Information

RIDADR 

UN2588 (Pesticide, solid, poi- sonous, n.o.s.); UN2902 (Pesticide, liquid, poisonous, n.o.s.)

HS Code 

29349990

Hazardous Substances Data

104653-34-1(Hazardous Substances Data)

Toxicity

LD50 orally in male, female rats, mice (mg/kg): 0.62, 0.42, 0.52, 0.43 (non-resistant); 0.27, 0.39, 0.46, 0.52 (warfarin resistant); LD50 in hare: 0.75 mg/kg; LC50 in mallard duck, bobwhite quail (ppm): 1.94, 0.56; LD50 at 48 hrs in daphnia magna, bluegill sunfish, rainbow trout (mg/l): 4.4, 110, 67 (Lechevin)

DIFETHIALONE Usage And Synthesis

Description

Difethialone[104653-34-1], 3-[(1RS,3RS; 1RS,3SR)-3- (4 -bromobiphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthyl]- 4-hydroxy-1-benzothiin-2-one, C31H23BrO2S, MW 539.5, mp 233–236 ?C, is a slightly yellowish powder which is practically insoluble in water, moderately soluble in ethanol, methanol, hexane, acetone, readily soluble in chloroform, dimethylformamide [9, p. 393].

Uses

Difethialone is an anticoagulant rodenticide widely used to control rodent infestations.

Uses

Pesticide.

Preparation

Difethialone is made by condensation of 4-hydroxy-2H- 1-benzothiapyran-2-one with 3-(4 -bromo-4-biphenyl)-1,2, 3,4-tetrahydro-1-naphthol in acetic acid containing concentrated sulfuric acid (62).

Definition

ChEBI: Difethialone is a member of benzenes, a member of naphthalenes and a ring assembly.

Agricultural Uses

Rodenticide, Pesticide: Introduced in 1986, this second-generation anticoagulant rodenticide (member of the hydroxy-4-benzothiopyranone family) is used to control mice and rats, including those resistant to first-generation anticoagulants. Not approved for use in most EU countries. Approved for use in the U.S.

Trade name

LM-2219®; PROTECTA RAT BAIT STATION®; VETERAN PELLET®; VETERAN WAX BLOCK®

DIFETHIALONE(104653-34-1)Related Product Information

• Quizalofop-p-ethyl
• 4-BROMO-4'-ETHYLBIPHENYL
• 4-BROMO-4'-PROPYLBIPHENYL
• S-PHENYL THIOPROPIONATE, 98
• 4-BROMO-4'-N-PENTYLBIPHENYL
• 5-(4-BIPHENYLYL)PENTANAL
• S-Methyl isovalerate
• 4-Hydroxylthiocoumarin
• 4-Bromo-4'-methylbiphenyl
• DIFETHIALONE