Basic information Safety Supplier Related

Benzyl-PEG8-azide

Basic information Safety Supplier Related

Benzyl-PEG8-azide Basic information

Product Name:
Benzyl-PEG8-azide
Synonyms:
  • Benzyl-PEG8-azide
  • Benzyl-PEG7-azide
  • Benzyl-PEG7-N3
  • Benzyl-PEG8-N3
  • 2,5,8,11,14,17,20-Heptaoxadocosane, 22-azido-1-phenyl-
CAS:
868594-42-7
MF:
C21H35N3O7
MW:
441.53
Mol File:
868594-42-7.mol
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Benzyl-PEG8-azide Usage And Synthesis

Biological Activity

Benzyl-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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