Cbz-N-amido-PEG5-acid Chemical Properties

Boiling point:

599.4±50.0 °C(Predicted)

Density 

1.180±0.06 g/cm3(Predicted)

storage temp. 

Store at Room Tem.

pka

4.28±0.10(Predicted)

Cbz-N-amido-PEG5-acid Usage And Synthesis

Description

Cbz-N-amido-PEG5-acid is a PEG linker containing a CBZ-protected amino group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected by acidic conditions.

Uses

Cbz-NH-PEG5-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Cbz-N-amido-PEG5-acid(1347750-74-6)Related Product Information

• Deionized water
• Cbz-N-amido-PEG3-acid
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