ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > evobrutinib
evobrutinib
evobrutinib Basic information
- Product Name:
- evobrutinib
- Synonyms:
-
- MSC2364447C
- M2951
- M2951; MSC2364447C
- 140920
- evobrutinib
- 1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one
- 1-[4-({[6-Amino-5-(4-phenoxyphenyl)-4-pyrimidinyl]amino}methyl)-1-piperidinyl]-2-propen-1-one
- M-2951 (Evobrutinib)
- CAS:
- 1415823-73-2
- MF:
- C25H27N5O2
- MW:
- 429.51
- Product Categories:
-
- API
- Mol File:
- 1415823-73-2.mol
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evobrutinib Chemical Properties
- Melting point:
- 173 - 174oC
- Boiling point:
- 683.4±55.0 °C(Predicted)
- Density
- 1.227±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 5.29±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
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evobrutinib Usage And Synthesis
Uses
Evobrutinib is a highly selective inhibitor of the Bruton’s tyrosine kinase (BTK), which is important in the -development and functioning of various immune cells including B -lymphocytes and macrophages. Preclinical research suggests it may be therapeutically useful in certain autoimmune diseases.
in vivo
Evobrutinib (0.3, 1, 3, 10, or 30 mg/kg, oral gavage, once daily) demonstrates efficacy in a rat model of rheumatoid arthritis[1].
| Animal Model: | Female Lewis rats with semi-established type II collagen arthritis[1]. |
| Dosage: | 0.3, 1, 3, 10, or 30 mg/kg. |
| Administration: | Oral gavage once daily for 11 days (days 6-16). |
| Result: | Reduced ankle histopathology scores in a dose-dependent manner, compared to vehicle. |
evobrutinibSupplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Shanghai Topbiochem Technology Co., Ltd
- Tel
- 021-58170097
- info@topbiochem.com
Bide Pharmatech Ltd.
- Tel
- 400-400-164-7117 18317119277
- product02@bidepharm.com
AdooQ Bioscience CHINA
- Tel
- 025-58849295 18951903616;
- info@adooq.cn
Shanghai XingMo Biotechnology Co., Ltd.
- Tel
- +86 13524779951; 13524779951
- 2075692521@qq.com