DMT-2'-Fluoro-dG(Ib) Phosphoramidite
DMT-2'-Fluoro-dG(Ib) Phosphoramidite Basic information
- Product Name:
- DMT-2'-Fluoro-dG(Ib) Phosphoramidite
- Synonyms:
-
- 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-(2-methyl-1-oxopropyl)guanosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
- DMT-2FLUORO-DG(IB) AMIDITE
- DMT-2'-F-dG(iBu)-CE Phosphoramidite
- 2'-F-dG(iBu)-CE Phosphoramidite
- 5'-O-DMT-2'-fluoro-N2-isobutyryl-2'-Deoxy-guanosine 3'-CE phosphoramidite
- N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]-6-oxo-3H-purin-2-yl]-2-methylpropanamide
- ibu-2'-F-dG Phosphoramidite
- 2'-fluoro-N2-isobutyryl-5'-O-(4, 4'-dimethoxytrityl)-2'-deoxyguanosine-3'-CE-Phosphoramidite
- CAS:
- 144089-97-4
- MF:
- C44H53FN7O8P
- MW:
- 857.91
- Product Categories:
-
- Amidite
- Mol File:
- 144089-97-4.mol
DMT-2'-Fluoro-dG(Ib) Phosphoramidite Chemical Properties
- storage temp.
- -20°C
- solubility
- DMSO : 100 mg/mL (116.56 mM)
- form
- powder
- pka
- 9.16±0.20(Predicted)
- color
- white to off-white
- InChI
- InChI=1/C44H53FN7O8P/c1-10-58-61(52(28(4)5)43(6,7)25-46)60-37-34(59-41(35(37)45)51-26-47-36-38(51)48-42(50-40(36)54)49-39(53)27(2)3)24-57-44(29-14-12-11-13-15-29,30-16-20-32(55-8)21-17-30)31-18-22-33(56-9)23-19-31/h11-23,26-28,34-35,37,41H,10,24H2,1-9H3,(H2,48,49,50,53,54)/t34-,35-,37-,41-,61?/s3
- InChIKey
- CFFUQMXILRDKMM-QPYLYBSMNA-N
- SMILES
- C(NC1=NC(=O)C2=C(N1)N([C@H]1[C@H](F)[C@H](OP(OCC)N(C(C)C)C(C#N)(C)C)[C@@H](COC(C3=CC=C(OC)C=C3)(C3=CC=C(OC)C=C3)C3=CC=CC=C3)O1)C=N2)(=O)C(C)C |&1:10,11,13,28,r|
DMT-2'-Fluoro-dG(Ib) Phosphoramidite Usage And Synthesis
Description
DMT-2'-Fluoro-dG(Ib) Phosphoramidite is a 2′Fluoro phosphoramidite that is used to synthesize oligonucleotides that are more thermally stable and provide increased nuclease resistance.
Uses
DMT-2''Fluoro-DG(IB) amidite (CAS# 144089-97-4) is a nucleoside used in the preparation of cyclic dinucleotide compounds, and in the preparation of 4''-C-methoxy-2''-deoxy-2''-fluoro modified ribonucleotides, which improve metabolic stability and elicit efficient RNAi-mediated gene silencing.
Definition
The key features of DMT-2'-Fluoro-dG(Ib) Phosphoramidite include, Can be employed together with DNA or RNA phosphoramidites Recommended deprotection conditions are 8 hours at 55 °C using concentrated ammonia solution, or with AMA for 10 minutes at 65 °C Synthesis of 2′Fluoro oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 3 minutes compared to 90 seconds for DNA monomers) Consistent lot-to-lot high purity and performance Manufactured under a certified ISO 9001 quality system.
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