p-Anisidine
p-Anisidine Basic information
- Product Name:
- p-Anisidine
- Synonyms:
-
- P-AMINOANISOLE
- 4-[4-(4-Aminophenyl)phenyl]aniline
- p,p'-Diaminoterphenyl
- 1,4-Anisidine
- p-Anisidine,95%,pract.
- 1-Methoxy-4-amino-benzen (p-anisidin)
- 1-Methoxy-4-amino-benzene / p-anisidine
- 4-Methoxy-1-aminobenzene
- CAS:
- 104-94-9
- MF:
- C7H9NO
- MW:
- 123.15
- EINECS:
- 203-254-2
- Product Categories:
-
- Thiophenes
- amine
- Intermediates
- Intermediates of Dyes and Pigments
- Anilines (Building Blocks for Liquid Crystals)
- Building Blocks for Liquid Crystals
- Functional Materials
- Mol File:
- 104-94-9.mol
p-Anisidine Chemical Properties
- Melting point:
- 56-59 °C(lit.)
- Boiling point:
- 240-243 °C(lit.)
- Density
- 1.06
- vapor density
- 4.28
- vapor pressure
- 0.02 hPa (20 °C)
- refractive index
- 1.5559
- Flash point:
- 122 °C
- storage temp.
- 2-8°C
- solubility
- 21g/l
- pka
- 5.34(at 25℃)
- form
- crystalline
- Specific Gravity
- 1.07
- color
- dark gray to brown
- PH
- 7.7 (1g/l, H2O, 20℃)
- Water Solubility
- 21 g/L (20 ºC)
- Merck
- 14,667
- BRN
- 471556
- Henry's Law Constant
- (x 10-8 atm?m3/mol): 6.62 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)
- Exposure limits
- NIOSH REL: TWA 0.5 mg/m3, IDLH 50 mg/m3; OSHA PEL: TWA 0.5 mg/m3; ACGIH TLV: TWA 0.1 ppm (adopted).
- CAS DataBase Reference
- 104-94-9(CAS DataBase Reference)
- IARC
- 3 (Vol. 27, Sup 7) 1987
- NIST Chemistry Reference
- Benzenamine, 4-methoxy-(104-94-9)
- EPA Substance Registry System
- p-Anisidine (104-94-9)
Safety Information
- Hazard Codes
- T+,N,Xi
- Risk Statements
- 45-26/27/28-33-50
- Safety Statements
- 53-28-36/37-45-61-28A
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 2
- RTECS
- BZ5450000
- F
- 8
- Autoignition Temperature
- 959 °F
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29222200
- Hazardous Substances Data
- 104-94-9(Hazardous Substances Data)
- Toxicity
- Acute oral LD50 for rats 1,400 mg/kg, mice 810 mg/kg, rabbits 2,900 mg/kg (quoted, RTECS, 1985).
MSDS
- Language:English Provider:4-Methoxybenzeneamine
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
p-Anisidine Usage And Synthesis
Chemical Properties
Anisidine exists as ortho-, meta-, and paraisomers. They have characteristic amine (fishy) odors.
Chemical Properties
grey to brown crystalline powder, granules
Physical properties
Yellow to light brown powder, leaflets, solid or crystals with a characteristic amine or ammonialike odor
Uses
p-Anisidine is used mostly for producing dyes, and some smaller quantities are employed in making pharmaceuticals and liquid crystals.
Uses
p-Anisidine is used as a reagent to indicate the secondary stage of the oxidation, it is one of the three possible isomers of the Anisidine or methoxyaniline. The other two isomers are o-Anisidine (2-methoxyaniline) and m-Anisidine (3-methoxyaniline).
The p-anisidine is widely used as an intermediate in the production of numerous azo and triphenylmethane dyes, and pigments. It is also used in the production of pharmaceuticals including the guaiacol expectorant, as an antioxidant for polymercaptan resins, and as a corrosion inhibitor for steel. Apart from the beneficial use of p-anisidine, it is toxic for human beings. The acute exposure may cause skin irritation, whereas the chronic exposure may cause headaches, vertigo, and blood complications like sulfhemoglobin, and methemoglobin. The oral exposure to anisidine hydrochloride resulted in cancer of the urinary bladder in male and female rats.
https://www.longdom.org/open-access/physicochemical-and-spectroscopic-characterization-of-biofield-energytreated-panisidine-paco-1000102.pdf
Uses
In the preparation of azo dyes; corrosion inhibitor; chemical intermediate
Synthesis Reference(s)
Journal of the American Chemical Society, 99, p. 98, 1977 DOI: 10.1021/ja00443a018
The Journal of Organic Chemistry, 49, p. 1434, 1984 DOI: 10.1021/jo00182a023
Tetrahedron Letters, 21, p. 2603, 1980 DOI: 10.1016/S0040-4039(00)92816-8
General Description
Brown crystals or dark brown solid. Characteristic amine odor.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
p-Anisidine may be sensitive to heat, light and moisture. Reacts with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. Incompatible with alkaline materials. Incompatible with aldehydes, ketones and nitrates.
Hazard
Strong irritant. Toxic when absorbed through the skin. Questionable carcinogen.
Fire Hazard
p-Anisidine is flammable.
Safety Profile
Moderately toxic by several routes. A mild sensitizer. May cause a contact dermatitis. Mutation data reported. Questionable carcinogen. See also ANILINE. When heated to decomposition it emits toxic fumes of Nox
Potential Exposure
Anisidines are used in the manufacture of azo dyes; pharmaceuticals; textile-processing chemicals Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks some coatings and some forms of plastic and rubber.
Carcinogenicity
Available data were inadequate to evaluate the carcinogenicity of p-anisidine.
Environmental Fate
Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).
Shipping
UN2431 Anisidines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Purification Methods
Crystallise p-anisidine from H2O or aqueous EtOH. Dry it in a vacuum oven at 35o for 6hours and store it in a dry box. [More et al. J Am Chem Soc 108 2257 1986.] Purify it also by vacuum sublimation [Guarr et al. J Am Chem Soc 107 5104 1985]. [Beilstein 13 IV 1015.]
Waste Disposal
Dissolve in combustible solvent (alcohols, benzene, etc.) and spray solution into furnace equipped with afterburner and scrubber, or burn spill residue on sand and soda ash absorbent in a furnace.
p-Anisidine Preparation Products And Raw materials
Preparation Products
Raw materials
p-AnisidineSupplier
- Tel
- 021-60899189-8001 18918189673
- gtchem@126.com
- Tel
- 0519-85267898-
- sales@guanjiachem.net;
- Tel
- 15250011737
- sales@abthg.com
- Tel
- 021-33516711;021-33516722
- kaisaichem1@163.com;kaisaichem1@163.com
- Tel
- 010-82848833- ;010-82848833-
- jkinfo@jkchemical.com;market6@jkchemical.com
p-Anisidine(104-94-9)Related Product Information
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