4-Aminoveratrole Chemical Properties

Melting point:

85-89 °C (lit.)

Boiling point:

174-176 °C/22 mmHg (lit.)

Density 

1.1577 (rough estimate)

refractive index 

1.4640 (estimate)

Flash point:

174-176°C/22mm

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Sparingly), Methanol (Slightly)

pka

4.78±0.10(Predicted)

form 

Crystalline Powder

color 

Brown

Water Solubility 

insoluble

BRN 

743399

InChI

1S/C8H11NO2/c1-10-7-4-3-6(9)5-8(7)11-2/h3-5H,9H2,1-2H3

InChIKey

LGDHZCLREKIGKJ-UHFFFAOYSA-N

SMILES

COc1ccc(N)cc1OC

CAS DataBase Reference

6315-89-5(CAS DataBase Reference)

NIST Chemistry Reference

Benzenamine, 3,4-dimethoxy-(6315-89-5)

EPA Substance Registry System

3,4-Dimethoxyaniline (6315-89-5)

Safety Information

Hazard Codes 

Xn,T,Xi

Risk Statements 

22-36/37/38-20/21/22

Safety Statements 

22-24/25-36/37/39-26-36

RIDADR 

2811

WGK Germany 

3

RTECS 

BX4550000

Hazard Note 

Toxic/Irritant

TSCA 

TSCA listed

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29222900

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Oral

MSDS

• Language:English Provider:1,2-Dimethoxy-4-aminobenzene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Aminoveratrole Usage And Synthesis

Chemical Properties

BROWN CRYSTALLINE POWDER

Uses

3,4-Dimethoxyaniline is commonly used as fine chemicals, used for pharmaceutical intermediates.

Synthesis Reference(s)

Tetrahedron Letters, 27, p. 4687, 1986 DOI: 10.1016/S0040-4039(00)85038-8

Synthesis

(1) Put 5000kg of methanol and 1250kg of 3,4-dimethoxynitrobenzene into the chemical kettle, and the subsequent feeding was carried out in accordance with the ratio, stirred well, pumped into the first-stage hydrogenation kettle, added 125kg of Pd/Al2O3 catalyst, with the particle size of catalyst of 10nm, passed into nitrogen replacement system for three times, and then passed into the hydrogen replacement system for three times, and turned on the stirring, and the temperature was raised to 90-100??. Temperature rise to 90-100 ??, with a flow rate of 6000L / h to the first hydrogenation kettle pumped into the 3,4-dimethoxynitrobenzene feedstock liquid, through the H2, the control system of hydrogen pressure of 1.0MPa, and every 3h interval to the first hydrogenation kettle to supplement the addition of Pd / Al2O3 catalyst 2.5kg, the first hydrogenation kettle of the gradual increase in the material through the overflow port into the secondary After gradually increasing the material in the first hydrogenation kettle, it will flow into the second hydrogenation kettle through the overflow port, and the material will stay in the hydrogenation kettle for about 2-3h, and the reaction will be qualified (with the residual amount of 3,4-dimethoxynitrobenzene ??0.2%), then it will overflow to the settlement kettle through the second hydrogenation kettle.

(2) The material is settled in the settling kettle, the lower catalyst is pumped into the hydrogenation kettle, the upper reducing solution is pumped into the membrane filtration system, the two membrane filters are connected in series, and the pump realizes the internal recycling, and the catalyst in the reducing solution is gradually concentrated to 10-30%, and the pump pumps the concentrated catalyst material into the catalyst charging tank to realize the internal recycling. The membrane used in this step is a ceramic membrane with an average pore size of 2 nm.

(3) After filtration of the reducing solution, it goes into a distillation kettle, and after warming up to remove the solvent methanol, the feed solution is put into a crystallization kettle, and after purification, the product of 3,4-dimethoxyaniline is obtained with a content of 99.9% and a production capacity of 950 kg/h.

4-Aminoveratrole(6315-89-5)Related Product Information

• m-Anisidine
• 4-(Trifluoromethoxy)aniline
• Dimethyldimethoxysilane
• Diphenyldimethoxysilane
• 1,1-Dimethoxyethane
• Phenetidine
• p-Anisidine
• Cyclopropanecarboxylic acid, 1-[[(2-fluorophenyl)amino]carbonyl]-
• Cabozantinib impurity 1DYH
• 1,1-Cyclopropanedicarboxamide, N,N'-bis[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-
• Cabozantinib Malate
• Cyclopropanecarboxylic acid, 1-[(phenylaMino)carbonyl]-
• Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)-
• 1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl-
• Cyclopropanecarboxylic acid, 1-[[[4-[[7-methoxy-6-(sulfooxy)-4-quinolinyl]oxy]phenyl]amino]carbonyl]-
• 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid
• Cabozantinib impurity DX2
• Cabozantinib Impurity EXA