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Cabozantinib impurity 1DYH

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Cabozantinib impurity 1DYH Basic information

Product Name:
Cabozantinib impurity 1DYH
Synonyms:
  • N-[4-[(6,7-Dimethoxy-1-oxido-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
  • Cabozantinib impurity 1DYH
  • 1,1-Cyclopropanedicarboxamide, N-[4-[(6,7-dimethoxy-1-oxido-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-
  • 4-(4-(1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carboxamido)phenoxy)-6,7-dimethoxyquinoline 1-oxide
  • N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-6,7-dimethoxyquinolin-4-amine
  • Cabozantinib Impurity 04
  • 4-(4-(1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxamido)phenoxy)-6,7-dimethoxyquinoline 1-oxide
CAS:
1621681-63-7
MF:
C28H24FN3O6
MW:
517.51
Mol File:
1621681-63-7.mol
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Cabozantinib impurity 1DYH Chemical Properties

Density 
1.36±0.1 g/cm3(Predicted)
pka
13.86±0.70(Predicted)
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Cabozantinib impurity 1DYH Usage And Synthesis

Uses

Cabozantinib N-oxide is a impurity of Cabozantinib (X745500), a medication used to treat medullary thyroid cancer. As well, it can be used in biological study. Computational network biological approach based on pathway cross-talk inhibition identified new synergistic drug combinations using raloxifene and cabozantinib for treatment of human breast cancer in xenograft mouse model. Potent c-MET inhibitor.

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