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5-Methoxyisatin

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5-Methoxyisatin Basic information

Product Name:
5-Methoxyisatin
Synonyms:
  • 5-METHOXY-2,3-INDOLINEDIONE
  • 5-METHOXYINDOLE-2,3-DIONE
  • 5-METHOXYISATIN
  • AKOS AU36-M122
  • 5-methoxy-1h-indole-2,3-dione
  • 5-methoxy-1h-indole-3-dione
  • 5-methoxy-indole-3-dione
  • 5-Methoxyisatin,98%
CAS:
39755-95-8
MF:
C9H7NO3
MW:
177.16
EINECS:
670-372-2
Product Categories:
  • Indane/Indanone and Derivatives
  • Indoline & Oxindole
  • Indoles
  • Simple Indoles
Mol File:
39755-95-8.mol
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5-Methoxyisatin Chemical Properties

Melting point:
201-203°C
Density 
1.346±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
9.73±0.20(Predicted)
color 
Orange to Amber to Dark red
Water Solubility 
Soluble in cold water.
InChI
InChI=1S/C9H7NO3/c1-13-5-2-3-7-6(4-5)8(11)9(12)10-7/h2-4H,1H3,(H,10,11,12)
InChIKey
DMHGXMPXHPOXBF-UHFFFAOYSA-N
SMILES
N1C2=C(C=C(OC)C=C2)C(=O)C1=O
CAS DataBase Reference
39755-95-8(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
RTECS 
NL7938000
HazardClass 
IRRITANT
HS Code 
29339900

MSDS

  • Language:English Provider:ALFA
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5-Methoxyisatin Usage And Synthesis

Chemical Properties

Dark red to brown solid

Uses

5-Methoxyisatin is used for Pharmaceutical intermediates, a raw material used in chemical synthesis.

Preparation

Using water as solvent, 5-methoxyaniline reacted with chloral hydrate and hydroxylamine hydrochloride at 90 ℃ for 3.5h to obtain p-methoxyisonitrosoacetanilide in 95% yield. After hydrolysis, 5-methoxyisatin was obtained in 88% yield by cyclization at 92℃ with concentrated H2SO4 (75%).

Definition

ChEBI: 5-Methoxyisatin is a member of indoles. It has a role as an anticoronaviral agent.

Synthesis Reference(s)

The Journal of Organic Chemistry, 42, p. 1344, 1977 DOI: 10.1021/jo00428a016

5-Methoxyisatin Preparation Products And Raw materials

Raw materials

Hydrochloric acidAcetic acid glacialSodium sulfateHydroxylamine hydrochloridep-AnisidineMethanesulfonic acidChloral hydrate

5-MethoxyisatinSupplier

Changzhou Chemscaler Pharmtech Co., Ltd. Gold
Tel
0519-81096292 15312577869
Email
chemscaler@yahoo.com.cn
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006608290; 18621169109
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market03@meryer.com
Alfa Aesar
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400-6106006
Email
saleschina@alfa-asia.com
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Email
Sales-CN@TCIchemicals.com
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