Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Inorganic chemistry >  Inorganic salts >  Hydrazine and hydroxylamine salts >  Hydroxylamine hydrochloride

Hydroxylamine hydrochloride

Basic information Safety Supplier Related

Hydroxylamine hydrochloride Basic information

Product Name:
Hydroxylamine hydrochloride
Synonyms:
  • OXAMMONIUM HCL
  • OXAMMONIUM HYDROCHLORIDE
  • hydroxyaminehydrochloride
  • hydroxylaminechloride
  • hydroxylaminechloride(1:1)
  • HydroxyLamine-Hydrochioride
  • HYDROXYLAMMONIUM CHLORIDE REAGENT (ACS), LOW MERCURY
  • HYDROXYLAMMONIUM CHLORIDE SOLUTION 50% AQUEOUS W/V
CAS:
5470-11-1
MF:
NH2OH·HCl
MW:
69.49
EINECS:
226-798-2
Product Categories:
  • Amination
  • Hydroxylamines
  • Anilines, Aromatic Amines and Nitro Compounds
  • Inorganics
  • Hydroxylamines (Unsubstituted)
  • Synthetic Organic Chemistry
  • Pharmaceutical Intermediates
  • Pharma material
Mol File:
5470-11-1.mol
More
Less

Hydroxylamine hydrochloride Chemical Properties

Melting point:
155-157 °C (dec.)(lit.)
Density 
1.67 g/mL at 25 °C(lit.)
vapor pressure 
0.054 Pa (50 °C)
storage temp. 
Store at +15°C to +25°C.
solubility 
470g/l
form 
Liquid
color 
White to off-white
PH
2.5-3.5 (25℃, 50mg/mL in H2O)
Water Solubility 
560 g/L (20 ºC)
Sensitive 
Hygroscopic
Merck 
14,4828
BRN 
3539763
Stability:
Substances to be avoided include strong oxidizing agents. Heating above 115 C may cause explosion; do not store above 65C. Moisture and air sensitive.
InChIKey
WTDHULULXKLSOZ-UHFFFAOYSA-N
CAS DataBase Reference
5470-11-1(CAS DataBase Reference)
EPA Substance Registry System
Hydroxylamine hydrochloride (5470-11-1)
More
Less

Safety Information

Hazard Codes 
Xn,N,E
Risk Statements 
22-36/38-43-48/22-50-40-21/22-2
Safety Statements 
22-24-37-61-36/37
RIDADR 
UN 2923 8/PG 2
WGK Germany 
3
RTECS 
NC3675000
21
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
28251000
Toxicity
LD50 orally in mice: 408 mg/kg (Riemann)

MSDS

More
Less

Hydroxylamine hydrochloride Usage And Synthesis

Chemical Properties

White crystals

Physical properties

Colorless monoclinic crystals; hygroscopic; decomposes slowly in moist air;density 1.67 g/cm3at 17°C; melts at 151°C (decomposes); highly soluble inwater (84g/100g at 20°C); soluble in lower alcohols and glycols; pH of 0.1molar solution 3.4.

Uses

Organic synthesis, photographic developer, medicine, controlled reduction reactions, nondiscoloring short-stopper for synthetic rubbers, antioxidant for fatty acids.

Uses

Hydroxylammonium-chloride is a reducing agent in photography; in synthetic and analytical chemistry; as an antioxidant for fatty acids and soaps; in textiles; in medicine; controlled reduction reactions; non-discoloring short stoppers for synthetic rubbers; reagent for enzyme reactivation; powerful reducing agent; converts aldehydes and ketones to oximes and acid chlorides to hydroxamic acids; catalyst, swelling agent, and copolymerization inhibitor in polymerization processes; in floor lacquers and as an antioxidant for fatty acids and soaps.

Preparation

Hydroxylamine hydrochloride is prepared by electrolytic reduction ofammonium chloride.

Biotechnological Applications

Hydroxylamine hydrochloride is a strong reducing agent that is useful in biochemical crosslinking applications, including the deacetylation of SATA and chemical cleavage of EGS and Sulfo-EGS. Hydroxylamine converts carbonyl compounds (aldehydes and ketones) to their oxime derivatives in the presence of a weak base. Therefore, crosslinkers and other compounds that contain a carbonyl within their structure are cleavable with hydroxylamine•HCl.
EGS  and its water-soluble analog, Sulfo-EGS, are homobifunctional, succinimidyl ester, amine-reactive crosslinkers useful for covalent stabilization of polypeptide multimers and protein:protein interactions. Unlike disulfidecontaining crosslinkers, EGS and Sulfo-EGS will not cleave by reducing SDS-PAGE conditions but may be cleaved when necessary with hydroxylamine.
SATA  and SATP are modification reagents for addition of sulfhydryl groups to proteins and other molecules containing primary amines. Such sulfhydryl addition is an important step in one popular method for preparing protein conjugates such as antibodies with horseradish peroxidase enzyme. The initial modification results in addition of an acetyl-protected sulfur, enabling storage of the modified protein; to make the sulfur available as a sulhydryl group (-SH) for the final conjugation reaction, hydroxylamine is used to remove the protecting acetyl group.
Hydroxylamine•HCl is more stable to oxidation than the free base form of hydroxylamine; nevertheless, always prepare hydroxylamine solutions immediately before use and store the product desiccated. Hydroxylamine•HCl is soluble in polar solvents such as water, ethanol, methanol, glycerol and propylene glycol.

General Description

Colorless or off-white crystalline solid. pH (0.1 molar aqueous solution) 3.4. pH (0.2 molar aqueous solution) 3.2.

Air & Water Reactions

Hygroscopic. Sensitive to prolonged exposure to air. Water soluble. Reacts slowly with water.

Reactivity Profile

A powerful reducing agent. Reacts with bases and oxidizing agents.

Hazard

Toxic by ingestion, strong irritant to tissue.

Fire Hazard

Flash point data for Hydroxylamine hydrochloride are not available; however, Hydroxylamine hydrochloride is probably combustible.

Contact allergens

Hydroxylamine and its salts are used in various branches of industry, as reducing agents in color film developers or as reagents in laboratories.

Purification Methods

Crystallise the salt from aqueous75% ethanol or boiling methanol, and dry it under vacuum over CaSO4 or P2O5. It has also been dissolved in a minimum of water and saturated with HCl; after three such crystallisations, it is dried under a vacuum over CaCl2 and NaOH. Its solubility at 20o is 85% in H2O, 6% in EtOH and 12% in MeOH. [Hurd Inorg Synth I 87 1939, Semon in Org Synth Coll Vol I 318 1941.]

Hydroxylamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Hydroxylamine hydrochlorideSupplier

Wuxi tomorrow Chemical Technology Co., Ltd Gold
Tel
0510-80776682-
Email
2657909084@qq.com
Mashilabs (Shanghai) Co.,Ltd. Gold
Tel
021-54391580-
Email
info@mashilabs.com
Shanghai Aladdin Bio-Chem Technology Co.,LTD Gold
Tel
021-20337333-801
Email
market@aladdin-e.com
Ningbo Kunyu Pharmaceutical Technology Co., Ltd. Gold
Tel
0574-88327552
Email
bllp@foxmail.com
Nanjing Apicci Pharmaceutical Technology Co., Ltd. Gold
Tel
;
Email
2853590738@qq.com;2853579352@qq.com