2,3-DIMETHOXYBENZONITRILE Chemical Properties

Melting point:

68-70 °C(lit.)

Boiling point:

290.25°C (rough estimate)

Density 

1.2021 (rough estimate)

refractive index 

1.5300 (estimate)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in methanol.

form 

powder to crystal

color 

White to Light yellow

BRN 

1451651

CAS DataBase Reference

2024-83-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,T,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

RIDADR 

3276

WGK Germany 

3

RTECS 

DI4355000

HazardClass 

6.1

PackingGroup 

III

HS Code 

2926907090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,3-DIMETHOXYBENZONITRILE Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

3,4-Dimethoxybenzonitrile is used as an organic chemical synthesis intermediate.

Preparation

Veratraldoxime(88–89 g, 0.45 mol) was combined with acetic anhydride (100 g) in a 300-mL round-bottomed flask equipped with a ground-glass air condenser, and the mixture was cautiously heated. A vigorous reaction took place, at which point the flame (heating by oil bath; the author) was removed. After the reaction had subsided, the solution was gently refluxed for 2 h and then carefully poured, with stirring, into cold water (300 mL). Stirring was continued, and on cooling the nitrile separated as small, almost colorless crystals; these were collected by filtration and dried in air. The veratronitrile thus obtained was quite pure; yield 57–62 g (72–76%); mp 66–67 C°.

1-Cyanoacenaphthene 1403 can be synthesized from its carbaldoxime by dehydration with acetic anhydride in 87% yield. Whereas acetic anhydride usually serves as the solvent as well as the reactant, this procedure is performed in n-octane.

Synthesis Reference(s)

Synthesis, p. 510, 1985 DOI: 10.1055/s-1985-31253

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