Methyl 3-amino-4-methylthiophene-2-carboxylate Chemical Properties

Melting point:

85-88 °C (lit.)

Boiling point:

318.6±37.0 °C(Predicted)

Density 

1.264±0.06 g/cm3(Predicted)

Flash point:

>100°C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

1.71±0.10(Predicted)

form 

Solid

color 

Pale Yellow

Water Solubility 

1g/L at 35℃

BRN 

973196

InChIKey

YICRPERKKBDRSP-UHFFFAOYSA-N

LogP

1.28

CAS DataBase Reference

85006-31-1(CAS DataBase Reference)

NIST Chemistry Reference

Methyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25-22

WGK Germany 

2

Hazard Note 

Irritant

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Methyl 3-amino-4-methylthiophene-2-carboxylate Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

Methyl 3-Amino-4-methylthiophene-2-carboxylate is a versatile reactant used in various syntheses. It is used in the preparation of (oxalylamino)benzoic acids and (carboxyheteroarylamino)oxalic acids as selective and orally bioavailable nonpeptide inhibitors of protein-tyrosine phosphatase 1B.

Application

methyl 3-amino-4-methylthiophene-2-carboxylate is the starting material used in the synthesis of the local anesthetic articaine.
7-Methylthieno[3,2-d]pyrimidin-4(3H)-one was prepared using methyl 3-amino-4-methylthiophene-2-carboxylate.
The reaction of 4-bromotoluene (0.171 g, 1 mmol), methyl 3-amino-4-methylthiophene-2-carboxylate(0.342 g, 2 mmol) and KOAc (0.196 g, 2 mmol) in the presence of PdCl(C3H5)(dppb) (12.2 mg, 0.02mmol) in DMAc at 120 °C affords the corresponding Methyl 3-amino-4-methyl-5-p-tolylthiophene-2-carboxylate in 81% (0.212 g) isolated yield.

Definition

ChEBI: Methyl 3-amino-4-methylthiophene-2-carboxylate is a thiophenecarboxylic acid.

Methyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1)Related Product Information

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• METSULFURON METHYL
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• METHYL 3-AMINO-4-CYANOTHIOPHENE-2-CARBOXYLATE