Basic information Safety Supplier Related

LDN 193189 hydrochloride

Basic information Safety Supplier Related

LDN 193189 hydrochloride Basic information

Product Name:
LDN 193189 hydrochloride
Synonyms:
  • LDN-193189 2HCl
  • LDN 193189 dihydrochloride
  • 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
  • Viomycin LDN 193189 Dihydrochloride
  • DM-3189 2HCl
  • LDN-193189 2HC
  • LDN-193189 (DM3189) 2HCl
  • LDN-193189 2HCl|||DM-3189 2HCl
CAS:
1435934-00-1
MF:
C25H24Cl2N6
MW:
479.40426
Mol File:
1435934-00-1.mol
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LDN 193189 hydrochloride Chemical Properties

storage temp. 
-20°C
solubility 
Soluble in DMSO or in Water (up to 5 mg/ml)
form 
solid
color 
Orange-yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
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LDN 193189 hydrochloride Usage And Synthesis

Description

LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.

storage

-20°C

References

1) Yu?et al.?(2008),?BMP type 1 receptor inhibition reduces heterotropic ossification; Nature Med.,14?1363 2) Chambers?et al.?(2012),?Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors; Nature Biotechnol.?30?715 3) Kreitzer?et al. (2013)?A robust method to derive functional neural crest cells from human pluripotent stem cells; Am. J. Stem Cells,?2?119 4) Lee?et al.?(2011)?BMP4 promotes prostate tumor growth in bone through osteogenesis; Cancer Res.?71?5194

LDN 193189 hydrochlorideSupplier

UHN Shanghai Research & Development Co., Ltd.
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021-58958002 18930822973
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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ShangHai Biochempartner Co.,Ltd
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Shanghai Rechem science Co., Ltd.
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Shanghai Chaolan Chemical Technology Center
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