LDN 193189 hydrochloride
- Product Name
- LDN 193189 hydrochloride
- CAS No.
- 1435934-00-1
- Chemical Name
- LDN 193189 hydrochloride
- Synonyms
- DM-3189 2HCl;LDN-193189 2HC;LDN-193189 2HCl;LDN-193189 2HCl ，S7507;DM-3189 dihydrochloride;LDN-193189 (DM3189) 2HCl;LDN 193189 dihydrochloride;LDN-193189 2HCl|||DM-3189 2HCl;LDN-193189 2HCl, 10 mM in DMSO;Viomycin LDN 193189 Dihydrochloride
- CBNumber
- CB03146321
- Molecular Formula
- C25H24Cl2N6
- Formula Weight
- 479.40426
- MOL File
- 1435934-00-1.mol
LDN 193189 hydrochloride Property
- storage temp.
- -20°C
- solubility
- Soluble in DMSO or in Water (up to 5 mg/ml)
- form
- solid
- color
- Orange-yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 19396
- Product name
- LDN-193189 (hydrochloride)
- Packaging
- 5mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 19396
- Product name
- LDN-193189 (hydrochloride)
- Packaging
- 25mg
- Price
- $219
- Updated
- 2024/03/01
- Product number
- 19396
- Product name
- LDN-193189 (hydrochloride)
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 19396
- Product name
- LDN-193189 (hydrochloride)
- Packaging
- 10mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 6053
- Product name
- LDN193189dihydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $216
- Updated
- 2021/12/16
LDN 193189 hydrochloride Chemical Properties,Usage,Production
Description
LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.
Uses
LDN-193189 (dihydrochloride) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva[1][2][3].
in vivo
LDN-193189 (i.p.; 3 mg/kg; daily; for 35 days) might affect the interaction between breast cancer cells and the bone environment[3].
LDN-193189 (i.p.; 3 mg/kg; single) shows a reduction in ectopic ossification and functional impairment[1].
storage
-20°C
References
[1] BMP type 1 receptor inhibition reduces heterotropic ossification
[2] STUART M CHAMBERS. Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors[J]. Nature biotechnology, 2012, 30 7: 715-720. DOI:10.1038/nbt.2249
[3] FAITH R KREITZER. A robust method to derive functional neural crest cells from human pluripotent stem cells.[J]. American journal of stem cells, 2013, 2 2: 119-131.
[4] YU-CHEN LEE. BMP4 promotes prostate tumor growth in bone through osteogenesis.[J]. Cancer research, 2011: 5194-5203. DOI:10.1158/0008-5472.can-10-4374
LDN 193189 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
LDN 193189 hydrochloride Suppliers
- Tel
- 021-58958002 18930822973
- Fax
- +86 (21) 5895-8628
- sales@uhnshanghai.com
- Country
- China
- ProdList
- 998
- Advantage
- 58
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39999
- Advantage
- 60
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 86249
- Advantage
- 60
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 7999
- Advantage
- 62
- Tel
- 021-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2991
- Advantage
- 58
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9550
- Advantage
- 58
- Tel
- 13761310616
- Fax
- QQ: 39324283
- 39324283@qq.com
- Country
- China
- ProdList
- 1377
- Advantage
- 58
- Tel
- 021-58111628 15800915896
- Fax
- QQ 3285589261
- sales@twochem.com
- Country
- China
- ProdList
- 1788
- Advantage
- 58
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58