ChemicalBook > CAS DataBase List > LDN 193189 hydrochloride

LDN 193189 hydrochloride

Product Name
LDN 193189 hydrochloride
CAS No.
1435934-00-1
Chemical Name
LDN 193189 hydrochloride
Synonyms
DM-3189 2HCl;LDN-193189 2HC;LDN-193189 2HCl;LDN-193189 2HCl ，S7507;DM-3189 dihydrochloride;LDN-193189 (DM3189) 2HCl;LDN 193189 dihydrochloride;LDN-193189 2HCl|||DM-3189 2HCl;LDN-193189 2HCl, 10 mM in DMSO;Viomycin LDN 193189 Dihydrochloride
CBNumber
CB03146321
Molecular Formula
C25H24Cl2N6
Formula Weight
479.40426
MOL File
1435934-00-1.mol
More
Less

LDN 193189 hydrochloride Property

storage temp. 
-20°C
solubility 
Soluble in DMSO or in Water (up to 5 mg/ml)
form 
solid
color 
Orange-yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Packaging
5mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Packaging
25mg
Price
$219
Updated
2024/03/01
Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Packaging
10mg
Price
$100
Updated
2024/03/01
Tocris
Product number
6053
Product name
LDN193189dihydrochloride
Purity
≥98%(HPLC)
Packaging
10
Price
$216
Updated
2021/12/16
More
Less

LDN 193189 hydrochloride Chemical Properties,Usage,Production

Description

LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC50 value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC50s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC50s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.

Uses

LDN-193189 (dihydrochloride) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva[1][2][3].

in vivo

LDN-193189 (i.p.; 3 mg/kg; daily; for 35 days) might affect the interaction between breast cancer cells and the bone environment[3].
LDN-193189 (i.p.; 3 mg/kg; single) shows a reduction in ectopic ossification and functional impairment[1].

storage

-20°C

References

[1] BMP type 1 receptor inhibition reduces heterotropic ossification
[2] STUART M CHAMBERS. Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors[J]. Nature biotechnology, 2012, 30 7: 715-720. DOI:10.1038/nbt.2249
[3] FAITH R KREITZER. A robust method to derive functional neural crest cells from human pluripotent stem cells.[J]. American journal of stem cells, 2013, 2 2: 119-131.
[4] YU-CHEN LEE. BMP4 promotes prostate tumor growth in bone through osteogenesis.[J]. Cancer research, 2011: 5194-5203. DOI:10.1158/0008-5472.can-10-4374

LDN 193189 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

LDN 193189 hydrochloride Suppliers

China 63 United Kingdom 1 United States 8 USA 1 Global 73
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
sales@uhnshanghai.com
Country
China
ProdList
998
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2990
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9126
Advantage
58
Dezhou LonWel Pharmaceutical Technology Co., Ltd.
Tel
13761310616
Fax
QQ: 39324283
Email
39324283@qq.com
Country
China
ProdList
1641
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58

1435934-00-1, LDN 193189 hydrochlorideRelated Search:

Z-FY-CHO 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Ibandronate sodium monohydrate 20ALPHA-HYDROXYCHOLESTEROL

  • LDN-193189 2HCl
  • LDN 193189 dihydrochloride
  • 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
  • Viomycin LDN 193189 Dihydrochloride
  • DM-3189 2HCl
  • LDN-193189 2HC
  • LDN-193189 (DM3189) 2HCl
  • LDN-193189 2HCl|||DM-3189 2HCl
  • 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline dihydrochloride
  • LDN 193189 in solution New
  • LDN-193189 2HCl, 10 mM in DMSO
  • LDN-193189 2HCl ，S7507
  • DM-3189 dihydrochloride
  • 1435934-00-1
  • C25H24Cl2N6