ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > SZL P1-41
SZL P1-41
SZL P1-41 Basic information
- Product Name:
- SZL P1-41
- Synonyms:
-
- SZL P1-41
- 3-(benzo[d]thiazol-2-yl)-6-ethyl-7-hydroxy-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
- 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
- 4H-1-Benzopyran-4-one, 3-(2-benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-
- SZL P1-41,E1 activating enzyme,Ubiquitin ligase,Apoptosis,E2 conjugating enzyme,Ubiquitin conjugating enzyme,E3 ligating enzyme,Inhibitor,E1/E2/E3 Enzyme,Ubiquitin activating enzyme,SZL P-1-41,SZL P141,SZL P1 41,inhibit
- SZL P1-41, 10 mM in DMSO
- SZL P1-41 ，S9724
- CAS:
- 222716-34-9
- MF:
- C24H24N2O3S
- MW:
- 420.52
- Mol File:
- 222716-34-9.mol
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SZL P1-41 Chemical Properties
- Melting point:
- 204-207°C
- Boiling point:
- 610.0±65.0 °C(Predicted)
- Density
- 1.340±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 6.06±0.20(Predicted)
- color
- Yellow
- Stability:
- Hygroscopic
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SZL P1-41 Usage And Synthesis
Uses
3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one is involved in the pharmacological inactivation of Skp2 E3 ligase.
Definition
ChEBI: SZL-P1-41 is a chromone that is 3-(1,3-benzothiazol-2-yl)-8-(1-piperidinylmethyl)chromen-4-one bearing additional ethyl and hydroxy substituents at positions 6 and 7 respectively. It has a role as an antineoplastic agent and an EC 6.3.2.19 (ubiquitin--protein ligase) inhibitor. It is a member of benzothiazoles, a member of chromones, a member of piperidines and a member of phenols.
in vivo
SZL P1-41 (40-80 mg/kg; i.p.) displays a potent effect on inhibiting prostate and lung tumor growth in Nude mice bearing A549 and PC3 tumor xenografts[1].
storage
Store at +4°C
SZL P1-41Supplier
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185 18149758185;
- sales-cpd@caerulumpharma.com
ShangHai Angti Biotechnology Co., Ltd.
- Tel
- 13764913901
- info@angtibio.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com