YKL-05-099 Chemical Properties

Boiling point:

761.0±70.0 °C(Predicted)

Density 

1.311±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO:103.33(Max Conc. mg/mL);172.18(Max Conc. mM)

form 

A solid

pka

8.63±0.20(Predicted)

color 

White to light yellow

YKL-05-099 Usage And Synthesis

Biological Activity

Potent and selective salt-inducible kinases (SIK1, SIK2, SIK3) inhibitor in vitro and in vivo.



YKL-05-099 is a potent and selective salt-inducible kinases inhibitor (SIK1/2/3 IC50 = 10/40/30 nM) with superior pharmacokinetic properties than HG-9-91-01. YKL-05-099 pre-treatment of murine BDMCs up-regulates Zymosan A-stimulated IL-10 (EC50 = 460 nM with 24h ), while suppresses inflammatory cytokines production (TNFα, IL-6 and IL-12p40). Likewise, YKL-05-099 intraperitoneal administration in mice (20 mg/kg i.p.) 15 min prior to LPS (0.5 mg/kg i.p.) enhances serum IL-10, while reduces HDAC5 pSer259 levels in total splenic leukocytes and serum TNFα level in vivo.

YKL-05-099(1936529-65-5)Related Product Information

• YKL 06-061
• YKL-06-062
• YKL-5-124