3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-
3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy- Basic information
- Product Name:
- 3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-
- Synonyms:
-
- 3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-
- HO-PEG4-CH2COOH
- Hydroxy-PEG4-CH2CO2H, sodium salt
- Hydroxy-PEG4-CH2CO2H
- 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]aceticacid
- 14-hydroxy-3,6,9,12-tetraoxatetradecanoic acid
- HO-PEG4-CH2COOH/3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy-
- CAS:
- 70678-95-4
- MF:
- C10H20O7
- MW:
- 252.26
- Product Categories:
-
- PROTAC LINKER
- Mol File:
- 70678-95-4.mol
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3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy- Chemical Properties
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- color
- Colorless to light yellow
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3,6,9,12-Tetraoxatetradecanoic acid, 14-hydroxy- Usage And Synthesis
Description
Hydroxy-PEG4-CH2CO2H, sodium salt, is a PEG derivative containing a hydroxyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
Uses
Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
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