Basic information Safety Supplier Related

BENZIODARONE

Basic information Safety Supplier Related

BENZIODARONE Basic information

Product Name:
BENZIODARONE
Synonyms:
  • BENZIODARONE
  • 2-Ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl ketone
  • Vasilar
  • 2329labaz
  • 2-ethyl-3-(3’,5’-diiodo-4’-hydroxybenzoyl)-cumarone
  • 3-(3,5-diiodo-4-hydroxybenzoyl)-2-ethyl-benzofura
  • 3,5-diiodo-4-hydroxyphenyl2-ethyl-3-benzofuranylketone
  • aethyl-2-(3’,5’-dijod-4’-oxybenzoyl)-3cumaron
CAS:
68-90-6
MF:
C17H12I2O3
MW:
518.08
EINECS:
200-695-2
Product Categories:
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
68-90-6.mol
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BENZIODARONE Chemical Properties

Melting point:
167°
Density 
1.9173 (estimate)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form 
Solid
color 
Beige
Water Solubility 
5.881mg/L(20 ºC)
CAS DataBase Reference
68-90-6
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Safety Information

HS Code 
2906.19.5000
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BENZIODARONE Usage And Synthesis

Originator

Amplivix,Sigma-Tau

Uses

Benziodarone is a uricosuric drug,it is used to effectively to control hyperuricemia in renal transplantation.

Definition

ChEBI: Benziodarone is an aromatic ketone.

Manufacturing Process

The starting product 2-ethyl-3-benzofuranyl p-hydroxyphenyl ketone (benzaron) was prepared in 4 steps:
1. First step was a reaction of salicylic aldehyde with chloroacetone to produce 2-acetyl-1-benzofuran.
2. It was reduced by hydrazine hydrate in an alkaline medium by process of Hyuang-Minlon, J.A.C.S., 1946, 68, 2487 to give 2-ethyl-1-benzofurane.
3. 2-Ethyl-3-(4-methoxybenzoyl)-1-benzofuran was obtained from 2-ethyl-1- benzofuran and 4-methoxy-benzoylchloride in a presence of tin tetrachloride. 4. It was heated with pyridine hydrochloride at 200°-220°C to give 2-ethyl-3- benzofuranyl p-hydroxyphenyl ketone (benzaron) as described in N.P.B.Hoi, C.Beaudet; US Patent No. 3,012,042; Dec. 5, 1961.
Benzaron (1 part) was dissolved in a very slight excess of 3% caustic soda. To this solution is gradually added a slight excess of iodine dissolved in a 25% aqueous solution of potassium iodide. The resultant solution is acidified with a 20% solution of sodium bisulphite, centrifuged, washed with water and then recrystallized in acetic acid to give of 2-ethyl-3-benzofuranyl 4-hydroxy-3,5- diiodophenyl ketone. MP: 167°C.

Therapeutic Function

Coronary vasodilator, Uricosuric

Safety Profile

A poison bj7 intraperitoneal and intravenous routes. Moderately toxic by ingestion. A flammable liquid. When heated to decomposition it emits toxic vapors of I-.

BENZIODARONESupplier

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