BMS711939 Chemical Properties

Boiling point:

650.1±65.0 °C(Predicted)

Density 

1.379±0.06 g/cm3(Predicted)

pka

3.90±0.10(Predicted)

BMS711939 Usage And Synthesis

Uses

BMS711939 is a selective agonist for peroxisome proliferator-activated receptor α (PPAR α), with EC50 of 4 nM and 4.5 μM, for human PPARα and human PPARγ. BMS711939 exhibits good pharmacokinetic characters in rats models. BMS711939 increases HDL cholesterol, reduces LDL cholesterol and triglycerides[1].

IC 50

hPPARα: 4 nM (IC₅₀); hPPARγ: 4.5 μM (IC₅₀)

References

[1] Shi Y, et al., Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist. ACS Med Chem Lett. 2016 Apr 4;7(6):590-4. DOI:10.1021/acsmedchemlett.6b00033