WRR483
WRR483 Basic information
- Product Name:
- WRR483
- Synonyms:
-
- WRR483
- 1-Piperazinecarboxamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[(1S)-1-(2-phenylethyl)-3-(phenylsulfonyl)-2-propen-1-yl]amino]carbonyl]butyl]-4-methyl-
- CAS:
- 1076088-50-0
- MF:
- C29H41N7O4S
- MW:
- 583.75
- Mol File:
- 1076088-50-0.mol
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WRR483 Usage And Synthesis
Description
WRR-483, an analogue of K-11777, is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. WRR-483 demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. WRR-483 binds covalently to the active site cysteine of the protease in a similar manner as other vinyl sulfone-based inhibitors. WRR-483 has potential to be developed as a treatment for Chagas' disease.