Benzenebutanamide, N-(3-methylbutyl)-α-[[3-[(4-methylphenyl)sulfonyl]-1-oxo-2-propen-1-yl]amino]-, (αS)- Chemical Properties

Boiling point:

724.4±60.0 °C(Predicted)

Density 

1.153±0.06 g/cm3(Predicted)

pka

12.63±0.46(Predicted)

form 

Solid

color 

White to off-white

Benzenebutanamide, N-(3-methylbutyl)-α-[[3-[(4-methylphenyl)sulfonyl]-1-oxo-2-propen-1-yl]amino]-, (αS)- Usage And Synthesis

Uses

WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer. WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells[1].

References

[1] Tomlin FM, et al. Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity. ACS Cent Sci. 2017 Nov 22;3(11):1143-1155. DOI:10.1021/acscentsci.7b00224

Benzenebutanamide, N-(3-methylbutyl)-α-[[3-[(4-methylphenyl)sulfonyl]-1-oxo-2-propen-1-yl]amino]-, (αS)-(2138924-36-2)Related Product Information

• WRN inhibitor 3
• WRR483
• WRN inhibitor 1
• WRN inhibitor 4
• WRN Protein, Human, Recombinant