PF04191834
PF04191834 Basic information
- Product Name:
- PF04191834
- Synonyms:
-
- PF04191834
- PF-4191834
- 2H-Pyran-4-carboxamide, tetrahydro-4-[3-[[4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio]phenyl]-
- PF-4191834 >=98% (HPLC)
- PF4191834,Lipoxygenase,PF 4191834,inhibit,LOX,PF 04191834,PF-4191834,PF04191834,Inhibitor
- CAS:
- 1029317-21-2
- MF:
- C22H23N3O2S
- MW:
- 393.5
- Mol File:
- 1029317-21-2.mol
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PF04191834 Chemical Properties
- Melting point:
- 173 °C
- Boiling point:
- 663.0±55.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 15.78±0.20(Predicted)
- color
- White to yellow
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PF04191834 Usage And Synthesis
Biological Activity
PF-4191834 (PF-04191834) is an orally active, non-iron-chelating, non-redox 5-lipoxygenase (5-LOX) inhibitor (IC50=229 nM), 5-LOX is about 300 times more selective than 12-LOX and 15-LOX, has no activity against cyclooxygenase, and is effective against inflammation and pain.
in vitro
PF-4191834 (PF-04191834) inhibits the synthesis of the 5-LOX products 5-HETE, 5-oxo-ETE, LTB4, and LTE4 with estimated IC 50 values between 100 and 190 nM and do not inhibit significantly the COX-1/2 enzymes or the 12- or 15-LOX enzymes at concentrations up to 30 μM. PF-4191834 (PF-04191834) exerts a concentration-dependent inhibition of human 5-LOX, with an IC 50 value of 130 nM and an IC 80 value of 370 nM.
target
| 5-LOX < span> |
PF04191834Supplier
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
Beijing Solarbio Science & Tecnology Co., Ltd.
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
HANGZHOU CLAP TECHNOLOGY CO.,LTD
- Tel
- 86-571-88216897,88216896 13588875226
- sales@hzclap.com
Energy Chemical
- Tel
- 021-58432009 400-005-6266
- marketing1@energy-chemical.com