N-DANSYL-D-ALA-GLY-4-NITRO-PHE-GLY
N-DANSYL-D-ALA-GLY-4-NITRO-PHE-GLY Basic information
- Product Name:
- N-DANSYL-D-ALA-GLY-4-NITRO-PHE-GLY
- Synonyms:
-
- Dansyl-D-Ala-Gly-4-nitro-Phe-Gly-OH trifluoroacetate salt
- Dansyl-D-Ala-Gly-4-nitro-Phe-Glu-OH
- N-DANSYL-D-ALA-GLY-4-NITRO-PHE-GLY
- N-DANSYL-D-ALA-GLY-P-NITRO-PHE-GLY
- 2-((S)-2-(2-((R)-2-(5-(diMethylaMino)naphthalene-1-sulfonaMido)propanaMido)acetaMido)-3-(4-nitrophenyl)propanaMido)acetic acid
- DANSYL-D-ALA-GLY-4-NITRO-PHE-GLY-OH TRIFLUOROACETATE
- Glycine, N-[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]-D-alanylglycyl-4-nitro-L-phenylalanyl-
- N-Dansyl-
D -Ala-Gly-p-nitro-Phe-Gly
- CAS:
- 83960-27-4
- MF:
- C28H32N6O9S
- MW:
- 628.65
- Product Categories:
-
- EnkephalinaseEnzyme Substrates
- Enkephalinase
- Enzyme Substrates
- Protease Substrates
- Substrates by Enzyme
- Mol File:
- 83960-27-4.mol
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N-DANSYL-D-ALA-GLY-4-NITRO-PHE-GLY Chemical Properties
- storage temp.
- −20°C
- solubility
- methanol: 50mg
- form
- powder
- Sequence
- {Dansyl}-{d-Ala}-Gly-{Phe(pNO2)}-Gly
MSDS
- Language:English Provider:SigmaAldrich
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N-DANSYL-D-ALA-GLY-4-NITRO-PHE-GLY Usage And Synthesis
Uses
Dansyl-D-Ala-Gly-Phe(pNO2)-Gly is a synthetic peptide substrate. As a substrate of NEP, Dansyl-D-Ala-Gly-Phe(pNO2)-Gly can be specifically recognized and cleaved by the enzyme, thereby releasing the fluorophore dansyl, which can be quantitatively detected. Therefore, it is often used to determine the activity of NEP[1].
References
[1] Niikura T, et al. A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice[J]. PloS one, 2011, 6(1): e16259. DOI:10.1371/journal.pone.0016259
N-DANSYL-D-ALA-GLY-4-NITRO-PHE-GLYSupplier
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