Basic information Safety Supplier Related

DANSYL ETHYLENEDIAMINE

Basic information Safety Supplier Related

DANSYL ETHYLENEDIAMINE Basic information

Product Name:
DANSYL ETHYLENEDIAMINE
Synonyms:
  • NSC 666752
  • 5-DIMETHYLAMINONAPHTHALENE-1-(N-(2-AMINOETHYL))-SULFONAMIDE
  • (2-AMINOETHYL)-DANSYLAMIDE
  • 2-(5-DiMethylaMino-1-naphthalenesulfonaMido)ethylaMine
  • N-(2-AMinoethyl)-5-(diMethylaMino)-1-naphthalenesulfonaMide
  • Dansyl ethylenediaMine [5-DiMethylaMinonaphthalene-1-(N-(2-aMinoethyl))sulfonaMide]
  • DNSEDA
  • N-(2-Aminoethyl)dansylamide
CAS:
35060-08-3
MF:
C14H19N3O2S
MW:
293.38
EINECS:
233-305-4
Product Categories:
  • Fluorescent Labels and Indicators
  • Fluorescent Labels & Indicators
Mol File:
35060-08-3.mol
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DANSYL ETHYLENEDIAMINE Chemical Properties

Melting point:
145-146°C
Boiling point:
470.2±55.0 °C(Predicted)
Density 
1.262±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
methanol: soluble1mg/mL, clear, slightly yellow to deep yellow
pka
11.30±0.50(Predicted)
form 
Solid
color 
Light Yellow
BRN 
2817535
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
38220090
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DANSYL ETHYLENEDIAMINE Usage And Synthesis

Description

Dansyl ethylenediamine is a lipophilic fluorophore that can be coupled to coarboxylic acids of proteins and other water-soluble polymers. The primary aliphatic amine of dansyl ethylenediamine can be reversibly coupled to aldehydes and ketones to form a Schiff base, which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3). Spectral data: λex=335nm, λem=525nm in methanol. Dansyl ethylenediamine has also shown to inhibit human renal dipeptidase (hrDP) irreversibly in a time-dependent manner.

Chemical Properties

Yellow to orange powder.

Uses

A fluorescent reagent.

References

[1] YUKI INOUE. Fluorescent molecularly imprinted polymer thin films for specific protein detection prepared with dansyl ethylenediamine-conjugated O-acryloyl l-hydroxyproline[J]. Biosensors and Bioelectronics, 2013. DOI:10.1016/j.bios.2013.03.005.
[2] ADACHIH. Importance of Glu-125 in the catalytic activity of human renal dipeptidase.[J]. Biochimica et biophysica acta, 1993. DOI:10.1016/0167-4838(93)90276-w.
[3] MALLAMPATI S, AERSCHOT A V, HOOGMARTENS J, et al. Analysis of dideoxyadenosine triphosphate by CE with fluorescence detection. I. Derivatization through the phosphate group[J]. ELECTROPHORESIS, 2007, 28. DOI:10.1002/elps.200700234.
[4] DUDLEY R W, SLOTTERBECK B D, MCINERNEY M F, et al. Fatty acylation enhances cellular localization of dansylated phenylalanines[J]. Molecular and Cellular Biochemistry, 2010, 346: 81-87. DOI:10.1007/s11010-010-0593-4.

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